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Interleukin-13 Receptor Subunit Alpha-2 (IL-13Rα2)

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Encyclopedia of Signaling Molecules

Synonyms

Cancer/testis antigen 19; CD213A2; CT19; IL-13 receptor subunit alpha-2; IL13BP; IL-13R; IL-13R subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13Rα2; Interleukin-13-binding protein

Historical Background

Interleukin (IL)-13 is an immune regulatory cytokine that plays an important role in allergy and atopic diseases (Hershey 2003; Karp 2004). It has two receptors, IL-13 receptor (IL-13R)α1 and IL-13Rα2. IL-13Rα1 monomer binds IL-13 with low affinity and mediates IL-13 cellular functions by pairing with IL-4 receptor (IL-4R)α. The IL-13 binding to IL-13Rα1/IL-4Rα heterodimer leads to activation of signal transducer and activator transcription (STAT)6 by Janus kinases (JAKs) (Miloux et al. 1997). IL-13Rα2 binds to IL-13 with high affinity but doesn’t mediate IL-13 cellular functions due to having a short cytoplasmic tail and no signaling motifs in it (Donaldson et al. 1998). The cDNA for IL-13Rα2 has first been isolated from human renal carcinoma cell lines. In 1996, Caput et al....

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Authors and Affiliations

  1. Institute of Life Science 1, School of Medicine, Swansea University, Singleton Park, SA2 8PP, Swansea, Wales, UK

    Riaz Jannoo & Venkateswarlu Kanamarlapudi

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  1. Riaz Jannoo
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  2. Venkateswarlu Kanamarlapudi
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Correspondence to Venkateswarlu Kanamarlapudi .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Jannoo, R., Kanamarlapudi, V. (2017). Interleukin-13 Receptor Subunit Alpha-2 (IL-13Rα2). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101987-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101987-1

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