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ADP-Ribosylation Factor-6 (ARF6)

  • Living reference work entry
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Encyclopedia of Signaling Molecules

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Synonyms

Adenosine diphosphate-ribosylation factor-6; ADP-ribosylation factor-6; ARF6; Arf6

Historical Background

The first member of the ADP-ribosylation factor (ARF) family (ARF1) was originally discovered in 1984 as a cofactor for cholera toxin-mediated ADP-ribosylation of the heterotrimeric G-protein Gs (Kahn and Gilman 1984). Since then it has been found to be a Ras-related small GTPase with molecular weight of ~21 kDa (Sewell and Kahn 1988). Use of Saccharomyces cerevisiae as a model system allowed the determination of a role for ARF1 in the secretory pathway, along with its intracellular localization at the Golgi (Stearns et al. 1990). ARFs are ubiquitously expressed in eukaryotic cells and are major regulators of intercellular vesicle trafficking. They have been found to be conserved across many species, including yeast, fish, insects, and animals, indicating an important role for them in cellular functions. Subsequent characterization of the ARF family in mammals has...

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Authors and Affiliations

  1. Institute of Life Science 1, School of Medicine, Swansea University, Swansea, Wales, SA2 8PP, UK

    Salman Tamaddon-Jahromi & Venkateswarlu Kanamarlapudi

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  1. Salman Tamaddon-Jahromi
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  2. Venkateswarlu Kanamarlapudi
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Correspondence to Venkateswarlu Kanamarlapudi .

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  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Tamaddon-Jahromi, S., Kanamarlapudi, V. (2016). ADP-Ribosylation Factor-6 (ARF6). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101965-1

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