The need for a specific transporter to mediate cellular glucose transport across the lipophilic cell membrane was first proposed in 1948 based on the observed saturable and isomer-specific nature of glucose uptake in human erythrocytes (LeFevre 1948). Continued work in this area led to the discovery an integral membrane protein with the ability to mediate glucose transport across the erythrocyte (Kasahara and Hinkle 1977). Cloning of this transporter in the HepG2 human hepatoma cell line in 1985 (Mueckler et al. 1985) and rat brain in 1986 (Birnbaum et al. 1986) led to the name “HepG2/rat brain/human erythrocyte transporter.” cDNA cloning of a glucose transporter abundantly expressed in the liver (and to a lesser extent in the kidney and intestine) occurred several years later (Fukumoto et al. 1988), and in the following year the first report of cDNA cloning of the glucose transporter predominantly expressed in rat...
KeywordsHydroxyl Lactate Carboxyl Diarrhea Luminal
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