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TNFAIP3 (Tumor Necrosis Factor, Alpha-Induced Protein 3)

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

A20; OTUD7C; Putative DNA-binding protein A20; TNF alpha-induced protein 3; Tumor necrosis factor inducible protein 3; Tumor necrosis factor, alpha-induced protein 3; Zinc finger protein A20

Historical Background

The intracellular ubiquitin-editing protein tumor necrosis factor alpha-induced protein 3 (TNFAIP3) has been characterized as a dual inhibitor in NF-κB signaling and cell death (Wertz et al. 2004). It is a primary response gene located on chromosome 6q23, originally identified as a gene in human umbilical vein endothelial cells whose expression is rapidly induced by tumor necrosis factor (TNF). The 80 kDa protein encoded by TNFAIP3 is the zinc finger protein A20, which has both ubiquitin ligase and deubiquitinase activities. A20, originally discovered in 1990, acts as a central and inducible endogenous negative feedback regulator of the NF-κB signaling pathway, the inappropriate activity of which has been linked to a host of autoimmune and inflammatory diseases...

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Authors and Affiliations

  1. Centre for Experimental Medicine, Queen’s University Belfast, Belfast, Northern Ireland, UK

    Rebecca McElroy, Madeleine Ennis & Bettina C. Schock

Authors
  1. Rebecca McElroy
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  2. Madeleine Ennis
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  3. Bettina C. Schock
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Correspondence to Rebecca McElroy or Bettina C. Schock .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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McElroy, R., Ennis, M., Schock, B.C. (2016). TNFAIP3 (Tumor Necrosis Factor, Alpha-Induced Protein 3). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101957-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101957-1

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  • Print ISBN: 978-1-4614-6438-9

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