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Tissue Inhibitor of Metalloproteinase

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

Synonyms

Metalloproteinase inhibitor; TIMP metallopeptidase inhibitor

Historical Background

In mammals, the tissue inhibitor of metalloproteinase (TIMP) family is comprised of four members, TIMP1-4. TIMPs are the primary inhibitors of metalloproteinases, such as the matrix metalloprotease (MMP) family, a disintegrin and metalloproteinase (ADAM) family, and the ADAMs with thrombospondin motifs (ADAMTS) family (Brew and Nagase 2010). TIMPs range in size from 22 to 28 kDA and are variably glycosylated (Murphy 2011). Further, each TIMP contains two distinct domains, an N-terminal and C-terminal domain of ~125 and 65 amino acids, respectively, connected through six conserved disulfide bonds (Brew and Nagase 2010; Murphy 2011). Each of these domains has critical roles in controlling TIMP function and localization.

The N-terminal domain, which folds independently and is composed of three α helices and five β strands arranged in a twisted β barrel, is critical for the inhibition of...

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References

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Authors and Affiliations

  1. Centre for Critical Illness Research, Lawson Health Research Institute, London, ON, Canada

    Marcello G. Masciantonio & Sean E. Gill

  2. Division of Respirology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Sean E. Gill

  3. Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Sean E. Gill

  4. Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

    Marcello G. Masciantonio & Sean E. Gill

Authors
  1. Marcello G. Masciantonio
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  2. Sean E. Gill
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Correspondence to Sean E. Gill .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Masciantonio, M.G., Gill, S.E. (2017). Tissue Inhibitor of Metalloproteinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101950-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101950-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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