Skip to main content

CDK4

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Baker SJ, Reddy EP. CDK4: a key player in the cell cycle, development, and cancer. Genes Cancer. 2012;3:658–69.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Blain SW. Switching cyclin D-Cdk4 kinase activity on and off. Cell Cycle. 2008;7:892–8.

    Article  CAS  PubMed  Google Scholar 

  • Buckley MF, Sweeney KJ, Hamilton JA, et al. Expression and amplification of cyclin genes in human breast cancer. Oncogene. 1993;8:2127–33.

    CAS  PubMed  Google Scholar 

  • Connell-Crowley L, Harper JW, Goodrich DW. Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. Mol Biol Cell. 1997;8:287–301.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Denicourt C, Dowdy SF. Cip/Kip proteins: more than just CDKs inhibitors. Genes Dev. 2004;18:851–5.

    Article  CAS  PubMed  Google Scholar 

  • Endicott J, Noble ME, Tucker JA. Cyclin-dependent kinases: inhibition and substrate recognition. Curr Opin Struct Biol. 1999;9:738–44.

    Article  CAS  PubMed  Google Scholar 

  • Fry DW, Harvey PJ, Keller PR, et al. Specific inhibition of cyclin-dependent kinase 4/6 by PD 0332991 and associated antitumor activity in human tumor xenografts. Mol Cancer Ther. 2004;3:1427–38.

    CAS  PubMed  Google Scholar 

  • Gil J, Peters G. Regulation of the INK4b-Arf-INK4a tumor suppressor locus: all for one and one for all. Nat Rev Mol Cell Biol. 2006;7:667–77.

    Article  CAS  PubMed  Google Scholar 

  • Grafstrom RH, Pan W, Hoess RH. Defining the substrate specificity of cdk4 kinase-cyclin D1 complex. Carcinogenesis. 1999;202:193–8.

    Article  Google Scholar 

  • Harbour JW, Dean DC. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 2000;14:2393–409.

    Article  CAS  PubMed  Google Scholar 

  • Kato JY, Matsuoka M, Strom DK, Sherr CJ. Regulation of cyclin D-dependent kinase 4 (cdk4) by cdk4-activating kinase. Mol Cell Biol. 1994;14:2713–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kitagawa M, Higashi H, Jung HK, et al. The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J. 1996;15:7060–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Malumbres M, Barbacid M. Cell cycle, CDKs and cancer: a changing paradigm. Nat Rev Cancer. 2009;9:153–66.

    Article  CAS  PubMed  Google Scholar 

  • Morgan DO. Cyclin-dependent kinases: engines, clocks, and microprocessors. Ann Rev Cell Dev Biol. 1997;13:261–91.

    Article  CAS  Google Scholar 

  • Rane SG, Dubus PD, Mettus RV, et al. Loss of cyclin-dependent kinase 4 expression causes infertility and insulin-dependent diabetes while its activation results in pancreatic islet hyperplasia. Nat Gen. 1999;22:44–52.

    Article  CAS  Google Scholar 

  • Takaki T, Echalier A, Brown NR, Hunt T, Endicott JA, Noble ME. The structure of CDK4/cyclin D3 has implications for models of CDK activation. Proc Natl Acad Sci USA. 2009;106:4171–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Toogood PL, Harvey PJ, Repine JT, et al. Discovery of a potent and selective inhibitor of cyclin-dependent kinase 4/6. J Med Chem. 2005;48:2388–406.

    Article  CAS  PubMed  Google Scholar 

  • VanArsdale T, Boshoff C, Arndt KT, Abraham RT. Molecular Pathways: targeting the cyclin D-CDK4/6 axis for cancer treatment. Clin Cancer Res. 2015;21:2905–10.

    Article  CAS  PubMed  Google Scholar 

  • Wolfel T, Hauer M, Schneider J, et al. A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma. Science. 1995;269:1281–4.

    Article  CAS  PubMed  Google Scholar 

  • Zuo L, Weger J, Yang Q, et al. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet. 1996;12:97–9.

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This work was supported by grants from the NIH (P01CA-130821), (NIH-RO1-CA-158209) to EPR.

Conflict of Interest Statement

The authors declare no conflicts of interest with respect to the authorship and publication of this article.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to E. Premkumar Reddy .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer Science+Business Media LLC

About this entry

Cite this entry

Baker, S.J., Reddy, E.P. (2017). CDK4. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101949-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101949-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics