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BATF

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 85 Accesses

Synonyms

B cell activating transcription factor; Basic leucine-zipper transcription factor, ATF-like; B-ATF; SFA-2; SFA2; SF-HT-activated gene-2

Historical Background

The basic leucine-zipper transcription factor, ATF-like (BATF) was first identified from a cDNA library of Epstein-Barr virus (EBV)-stimulated B cells, as a nuclear protein containing a basic leucine-zipper motif. A strong hybridization band for BATF was detected in poly-adenylated mRNA from cell lines and several human tissues such as the lung and Raji Burkitt’s lymphoma by Northern Blot analysis (Dorsey et al. 1995). Only a few months later, another study described a new bZIP transcription factor, which they called SF-HT-activated gene 2 (SFA-2), which was found highly expressed in T and B cells, especially when these cells were transformed by human T cell leukemia virus type I (HTLV-I) (Hasegawa et al. 1996).

Both studies showed that BATF does not form homodimers but builds heterodimers preferentially with Jun-family...

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References

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Authors and Affiliations

  1. Department of Molecular Pneumology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Universitätsklinikum Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany

    Nina Sopel & Susetta Finotto

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  1. Nina Sopel
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  2. Susetta Finotto
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Correspondence to Susetta Finotto .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Sopel, N., Finotto, S. (2016). BATF. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101936-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101936-1

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  • Print ISBN: 978-1-4614-6438-9

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