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SLC32

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 39 Accesses

Synonyms

SLC32A1; Solute carrier family 32; Vesicular GABA transporter; Vesicular inhibitory amino acid transporter; VGAT; VIAAT

Historical Background

Nerve terminals release neurotransmitters by exocytosis of synaptic vesicles, a process requiring prior accumulation within the vesicles. For “classical” (small-molecule) transmitters, this accumulation results from active transport of cytosolic transmitter across the vesicular membrane into the vesicle lumen. This transport involves a V-type proton-pumping ATPase, which acidifies and positively charges the vesicle lumen, and a secondary active transporter, which uses the proton electrochemical gradient across the vesicular membrane to accumulate specific transmitters (Edwards 2007).

The vesicular inhibitory amino acid transmitter (VIAAT), also known as vesicular GABA transporter (VGAT), ensures the vesicular uptake of the inhibitory amino acids GABA and glycine. VIAAT identification was initiated by genetic studies of GABAergic...

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References

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Author information

Authors and Affiliations

  1. Neurophotonics Laboratory (UMR 8250), Université Paris Descartes and Centre National de la Recherche Scientifique, 45 rue des Saints-Pères, 75006, Paris, France

    Bruno Gasnier

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  1. Bruno Gasnier
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Correspondence to Bruno Gasnier .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Gasnier, B. (2017). SLC32. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101902-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101902-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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