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Encyclopedia of Signaling Molecules pp 1–4Cite as

Tribbles Homolog 1

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Synonyms

C8FW; Skip1; Tribbles homolog 1; Trb1;

Historical Background

Trib1 is the member of tribbles family pseudokinases with Trib2 and Trib3 in mammals and is a homolog of Drosophila tribbles (Yokoyama and Nakamura 2011). Tribbles was first discovered as a regulator of string/cdc25 in morphogenesis (Grosshans and Wieschaus 2000). At same time, Mata et al. showed that tribbles induced degradation of string via the proteasome pathway (Mata et al. 2000). As a result of studies by these two groups, overexpression of tribbles was found to suppress cell cycle at G2 by proteasome-mediated degradation of string. Soon after discovery of tribbles in Drosophila, slbo/C/EBP was found to be regulated by tribbles also via proteasome pathway (Rorth et al. 2000). Mammalian homologs of tribbles consist of three closely related genes, Trib1/C8FW/SKIP1, Trib2/C5FW/SKIP2/SINK, and Trib3/NIPK/SKIP3 (Wilkin et al. 1997; Mayumi-Matsuda et al. 1999; Tang et al. 2000).

Structure of TRIB1 Pseudokinase

Both...

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References

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Authors and Affiliations

  1. Division of Carcinogenesis, The Cancer Institute, Japanese Foundation for Cancer Research, 135-8550, Tokyo, Japan

    Takuro Nakamura

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  1. Takuro Nakamura
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Correspondence to Takuro Nakamura .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Nakamura, T. (2016). Tribbles Homolog 1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101899-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101899-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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