Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Tribbles Homolog 1

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101899-1


Historical Background

Trib1 is the member of tribbles family pseudokinases with Trib2 and Trib3 in mammals and is a homolog of Drosophila tribbles (Yokoyama and Nakamura 2011). Tribbles was first discovered as a regulator of string/cdc25 in morphogenesis (Grosshans and Wieschaus 2000). At same time, Mata et al. showed that tribbles induced degradation of string via the proteasome pathway (Mata et al. 2000). As a result of studies by these two groups, overexpression of tribbles was found to suppress cell cycle at G2 by proteasome-mediated degradation of string. Soon after discovery of tribbles in Drosophila, slbo/C/EBP was found to be regulated by tribbles also via proteasome pathway (Rorth et al. 2000). Mammalian homologs of tribbles consist of three closely related genes, Trib1/C8FW/SKIP1, Trib2/C5FW/SKIP2/SINK, and Trib3/NIPK/SKIP3 (Wilkin et al. 1997; Mayumi-Matsuda et al. 1999; Tang et al. 2000).

Structure of TRIB1 Pseudokinase



Important Motif Mammalian Homolog Putative Nuclear Localization Signal Myeloid Cell Differentiation Suppress Cell Cycle 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Division of Carcinogenesis, The Cancer InstituteJapanese Foundation for Cancer ResearchTokyoJapan