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TRPV3 (Transient Receptor Potential Channel Subfamily V Member 3)

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  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

Transient receptor potential vanilloid 3; TRPV3; VRL3

Historical Background

TRPV3, a member of the subfamily V of transient receptor potential (TRP) channel family, was first identified as a temperature-sensitive nonselective cation channel by three independent research groups (Smith et al. 2002; Xu et al. 2002; Peier et al. 2002). TRPV3 channels have a large unitary conductance of about 150–200 pS and share 43% sequence homology with TRPV1, the capsaicin receptor. Like many other TRP channels, TRPV3 is a tetramer, and each subunit is composed of six transmembrane (TM) domains. The putative pore loop is located between TM5 and TM6 (Xu et al. 2002). TRPV3 is preferentially permeable to Ca2+, and its permeability ratio of Ca2+/Na+ is estimated to be around 10–15. Functional TRPV3 channel is present in both neuronal and non-neuronal tissues with a prominent expression in the skin, where it plays important roles in skin physiology and disease (Smith et al. 2002).

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References

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Authors and Affiliations

  1. The Center for the Study of Itch, Department of Anesthesiology, Washington University in Saint Louis, Saint Louis, MO, USA

    Jialie Luo & Hongzhen Hu

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  1. Jialie Luo
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  2. Hongzhen Hu
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Correspondence to Hongzhen Hu .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Luo, J., Hu, H. (2016). TRPV3 (Transient Receptor Potential Channel Subfamily V Member 3). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101877-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101877-1

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