Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

TRPV3 (Transient Receptor Potential Channel Subfamily V Member 3)

  • Jialie Luo
  • Hongzhen Hu
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101877-1


Historical Background

TRPV3, a member of the subfamily V of transient receptor potential (TRP) channel family, was first identified as a temperature-sensitive nonselective cation channel by three independent research groups (Smith et al. 2002; Xu et al. 2002; Peier et al. 2002). TRPV3 channels have a large unitary conductance of about 150–200 pS and share 43% sequence homology with TRPV1, the capsaicin receptor. Like many other TRP channels, TRPV3 is a tetramer, and each subunit is composed of six transmembrane (TM) domains. The putative pore loop is located between TM5 and TM6 (Xu et al. 2002). TRPV3 is preferentially permeable to Ca2+, and its permeability ratio of Ca2+/Na+ is estimated to be around 10–15. Functional TRPV3 channel is present in both neuronal and non-neuronal tissues with a prominent expression in the skin, where it plays important roles in skin physiology and disease (Smith et al. 2002).

Activation and...


Atopic Dermatitis Transient Receptor Potential Vanilloid Transient Receptor Potential Channel TRPV3 Channel Chronic Itch 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.The Center for the Study of Itch, Department of AnesthesiologyWashington University in Saint LouisSaint LouisUSA