TRPV3 (Transient Receptor Potential Channel Subfamily V Member 3)
TRPV3, a member of the subfamily V of transient receptor potential (TRP) channel family, was first identified as a temperature-sensitive nonselective cation channel by three independent research groups (Smith et al. 2002; Xu et al. 2002; Peier et al. 2002). TRPV3 channels have a large unitary conductance of about 150–200 pS and share 43% sequence homology with TRPV1, the capsaicin receptor. Like many other TRP channels, TRPV3 is a tetramer, and each subunit is composed of six transmembrane (TM) domains. The putative pore loop is located between TM5 and TM6 (Xu et al. 2002). TRPV3 is preferentially permeable to Ca2+, and its permeability ratio of Ca2+/Na+ is estimated to be around 10–15. Functional TRPV3 channel is present in both neuronal and non-neuronal tissues with a prominent expression in the skin, where it plays important roles in skin physiology and disease (Smith et al. 2002).
KeywordsAtopic Dermatitis Transient Receptor Potential Vanilloid Transient Receptor Potential Channel TRPV3 Channel Chronic Itch
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