Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Transient Receptor Potential Cation Channel Subfamily M Member 2

  • Lin-Hua Jiang
  • Sharifah Alawieyah Syed Mortadza
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101875-1

Synonyms

Historical Background

Transient receptor potential (TRP) cation channel subfamily M member 2 (TRPM2) was identified in the search for mammalian genes encoding homologues of the transient receptor potential (Trp) proteins that forms Ca2+-permeable cationic channels required for photo-transduction in Drosophila melanogaster fruit fly (Hardie and Minke 1992). It was firstly named the seventh classical TRP protein (TRPC7) that exhibits sequence relatedness with Drosophila Trp proteins (Nagamine et al. 1998) and subsequently renamed LTRPC2, the second member of the long TRP channel protein family characterized with exceptionally long N- and C-termini (Harteneck et al. 2000). In the efforts devoted to unifying...

Keywords

Permeability Obesity Ischemia Curcumin Borate 
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Notes

Acknowledgments

SSM is a recipient of Malaysian governmental scholarship. The researches in LHJ's lab described here have been supported by Wellcome Trust, Alzheimer’s Research Trust, Nature Science Foundation of China, Department of Education Henan Province, and Xinxiang Medical University. We apologize that we have not cited the literature in full due to space limitation.

References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Lin-Hua Jiang
    • 1
    • 2
  • Sharifah Alawieyah Syed Mortadza
    • 1
  1. 1.School of Biomedical SciencesUniversity of LeedsLeedsUK
  2. 2.Department of Physiology and Neurobiology, and Sino-UK Joint Laboratory of Brain Function and InjuryXinxiang Medical UniversityXinxiangPeople’s Republic of China