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Encyclopedia of Signaling Molecules pp 1–7Cite as

Tcf1

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Synonyms

T cell factor 1; Tcf1; TCF-1; Tcf7; Transcription factor 7, T cell specific transcription factor 1

Historical Background

Tcf1 transcription factor is a member of the Tcf/Lef family which consists of four members in vertebrates. Its orthologs in invertebrates include dTCF/pangolin in Drosophila and POP-1 in C. elegans (Arce et al. 2006; Cadigan 2012). Tcf1 was molecularly cloned in 1991 and found to be most abundantly expressed in T lymphocytes. In 1996, Lef1, a close homologue of Tcf1, was found to interact with β-catenin which is posttranslationally regulated by the Wnt signaling pathway. Since then, Tcf1, together with other members of Tcf/Lef family, is considered a Wnt effector transcription factor (Klaus and Birchmeier 2008). However, research efforts over the past two-and-half decades have revealed that Tcf1 interacts with several other transcription factors and cofactors, in addition to β-catenin, to cooperatively regulate gene transcription (Steinke and Xue 2014).

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References

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Iowa City Veteran Affairs Health Care Systems, Iowa City, IA, 52246, USA

    Dong-Mei Zhao

  2. Department of Microbiology, Carver College of Medicine, University of Iowa, Iowa City, IA, 52242, USA

    Hai-Hui Xue

Authors
  1. Dong-Mei Zhao
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  2. Hai-Hui Xue
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Corresponding author

Correspondence to Dong-Mei Zhao .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Zhao, DM., Xue, HH. (2016). Tcf1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101862-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101862-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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