Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101848-1


Historical Background

Matsumoto and his colleagues discovered the kinase transforming growth factor β-activated kinase 1 (TAK1) as a new member of MAP triple kinase (MAPKKK) in 1995 using yeast complementation screening (Yamaguchi et al. 1995). TAK1 is ubiquitously expressed in all tissues and four splicing variants have been reported in human. Structurally, TAK1 has an N-terminal kinase domain and a C-terminal regulatory domain. MAPKKK is a serine/threonine-specific protein kinase involved in cellular signal transduction, where MAPKKKs phosphorylate downstream dual-specificity protein kinase MAPKKs, which in turn phosphorylates the MAPKs to regulate a variety of biological events such as cell proliferation, migration, survival, and differentiation. TAK1 has been shown to activate MAPKK3/6 and MAPKK4/7, leading to downstream...


Polyubiquitin Chain TAK1 Inhibition Necroptotic Cell Death Downstream Executioner Caspases Regulate Reactive Oxygen Species Level 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Microbiology, Immunology, and Cancer BiologyUniversity of VirginiaCharlottesvilleUSA