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SerpinE1

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 220 Accesses

Synonyms

Endothelial plasminogen activator inhibitor; Mr1; Nexin, plasminogen activator inhibitor type 1; PAI; PAI1; PAI-1; Planh; PLANH1; Planh1; Plasminogen activator inhibitor 1; Plasminogen activator inhibitor type-1 (PAI-1); Plasminogen activator inhibitor-1; Serine (or cysteine) peptidase inhibitor, clade E, member 1; Serpine1; SERPINE1

Historical Background

The temporal and spatial control of a complex extracellular proteolytic cascade regulates the fundamental processes of tissue remodeling, inflammation, thrombosis, and wound repair. Growth factor and cytokine-induced release of two plasminogen activators (PAs; urokinase-type PA, uPA; tissue-type PA, tPA) converts plasminogen to plasmin, a trypsin-like protease that in turn activates several matrix metalloproteinases to implement extracellular matrix (ECM) restructuring (Van den Steen et al. 2001). The broad substrate specificity of plasmin requires strict control of its activity which is mainly accomplished by several...

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Authors and Affiliations

  1. Department of Regenerative and Cancer Cell Biology, Albany Medical College, Albany, NY, 12208, USA

    Ralf -Peter Czekay & Paul J. Higgins

  2. Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA

    Tessa M. Simone

Authors
  1. Ralf -Peter Czekay
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  2. Tessa M. Simone
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  3. Paul J. Higgins
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Corresponding author

Correspondence to Paul J. Higgins .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Czekay, R.P., Simone, T.M., Higgins, P.J. (2016). SerpinE1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101828-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101828-1

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  • Print ISBN: 978-1-4614-6438-9

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