Skip to main content
SpringerLink
Log in
Book cover

Encyclopedia of Signaling Molecules pp 1–7Cite as

Kallikrein-K1

  • Living reference work entry
  • First Online:

  • 56 Accesses

Synonyms

EC 3.4.21.35; Glandular kallikrein; KLK1 (hK1 or hKLK1 for man, mK1 or mKLK1 for mouse); KLKR; Tissue kallikrein; TK

Historical Background

Discovered as a hypotensive agent present in urine (Abelous and Bardier 1909; Frey and Kraut 1928). Hypotensive effect later assigned to release of vasodilator peptides, kinins, through enzymatic hydrolysis of protein precursors, kininogens (discovery of the enzymatic activity of kallikrein, Werle 1937).

First cloning of KLK1 gene in the mouse and description of the kallikrein gene family, followed by the rat and human kallikrein gene families, all subsequently expanded (Mason et al. 1983, Lundwall et al. 2006).

Inactivation of the KLK1 gene in the mouse (Meneton et al. 2001).

Description of the genetic determinism of urinary K1 activity in man and elucidation of its molecular basis (Zinner et al. 1976; Slim et al. 2002).

Kallikrein-K1 or tissue kallikrein should not be confounded with another enzyme called “plasma kallikrein” (KLKB1),...

This is a preview of subscription content, log in via an institution.

References

  • Abelous JE, Bardier E. Les substances hypotensives de l’urine humaine normale. CR Soc Biol. 1909;66:511–20.

    CAS  Google Scholar 

  • Azizi M, Boutouyrie P, Bissery A, Agharazii M, Verbeke F, Stern N, et al. Arterial and renal consequences of partial genetic deficiency in tissue kallikrein activity in humans. J Clin Invest. 2005 Mar;115(3):780–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Azizi M, Emanueli C, Peyrard S, Maddedu P, Alhenc-Gelas F, Campbell DJ. Genetic and dietary control of plasma tissue kallikrein secretion and urinary kinins excretion in man. J Hypertens. 2008 Apr;26(4):714–20.

    Article  CAS  PubMed  Google Scholar 

  • Bergaya S, Meneton P, Bloch-Faure M, Mathieu E, Alhenc-Gelas F, Levy B, Boulanger C. Decreased flow-dependent dilatation in carotid arteries of tissue kallikrein-knockout mice. Circ Res. 2001;88(6):593–9.

    Article  CAS  PubMed  Google Scholar 

  • Berry TD, Hasstedt SJ, Hunt SC, Wu LL, Smith JB, Ash KO, et al. A gene for high urinary kallikrein may protect against hypertension in Utah kindreds. Hypertension. 1989 Jan;13(1):3–8.

    Article  CAS  PubMed  Google Scholar 

  • Bodin S, Chollet C, Goncalves-Mendes N, Gardes J, Pean F, Heudes D, et al. Kallikrein protects against microalbuminuria in experimental type I diabetes. Kidney Int. 2009 Aug;76(4):395–403. doi:10.1038/ki.2009.208.

    Article  CAS  PubMed  Google Scholar 

  • Desposito D, Waeckel L, Potier L, Richer C, Roussel R, Bouby N, Alhenc-Gelas F. Kallikrein(K1)-kinin-kininase (ACE) and end-organ damage in ischemia and diabetes: therapeutic implications. Biol Chem. 2016 Dec 1;397(12):1217–22. doi:10.1515/hsz-2016-0228.

    Article  CAS  PubMed  Google Scholar 

  • Frey EK, Kraut H. Ein neues Kreislaufhormon und seine Wirkung. Naunyn-Schmiedeberg’s Arch Exp Pathol Pharmakol. 1928;133:1–12.

    Article  CAS  Google Scholar 

  • Griol-Charihbili V, Messadi-laribi E, Bascands JL, Heudes D, Meneton P, Giudicelli JF, et al. Role of tissue kallikrein in the cardioprotective effects of ischemic and pharmacological preconditioning in myocardial ischemia. FASEB J. 2005 Apr;19(9):1172–4. doi:10.1096/fj.04-3508fje.

    Google Scholar 

  • Kayashima Y, Smithies O, Kakoki M. The kallikrein-kinin system and oxidative stress. Curr Opin Nephrol Hypertens. 2012 Jan;21(1):92–6. doi:10.1097/MNH.0b013e32834 d54b1.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koid SS, Ziogas J, Campbell DJ. Aliskiren reduces myocardial ischemia-reperfusion injury by a bradykinin B2 receptor- and angiotensin AT2 receptor-mediated mechanism. Hypertension. 2014 Apr;63(4):768–73. doi:10.1161/HYPERTENSIONAHA.113.02902.

    Article  CAS  PubMed  Google Scholar 

  • Lundwall A, Band V, Blaber M, Clements JA, Courty Y, Diamandis EP, et al. A comprehensive nomenclature for serine proteases with homology to tissue kallikreins. Biol Chem. 2006 Jun;387(6):637–41.

    Article  CAS  PubMed  Google Scholar 

  • Margolius HS. Tissue kallikreins and kinins: regulation and roles in hypertensive and diabetic diseases. Annu Rev Pharmacol. 1989;29:343–64.

    Article  CAS  Google Scholar 

  • Mason AJ, Evans BA, Cox DR, Shine J, Richards RI. Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides. Nature. 1983;303:300–7.

    Article  CAS  PubMed  Google Scholar 

  • Meneton P, Bloch-Faure M, Hagege AA, Ruetten H, Huang W, Bergaya S, et al. Cardiovascular abnormalities with normal blood pressure in tissue kallikrein-deficient mice. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2634–9.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pathak M, Wong SS, Dreveny I, Emsley J. Structure of plasma and tissue kallikreins. Thromb Haemost. 2013 Sep;110(3):423–33. doi:10.1160/TH12-11-0840.

    Article  CAS  PubMed  Google Scholar 

  • Slim R, Torremocha F, Moreau T, Pizard A, Hunt SC, Vuagnat A, et al. Loss-of-function polymorphism of the human kallikrein gene with reduced urinary kallikrein activity. J Am Soc Nephrol. 2002;13:968–76.

    CAS  PubMed  Google Scholar 

  • Stone OA, Richer C, Emanueli C, van Weel V, Quax PH, Katare R, et al. Critical role of tissue kallikrein in vessel formation and maturation: implications for therapeutic revascularization. Arterioscler Thromb Vasc Biol. 2009 May;29(5):657–64. doi:10.1161/ ATVBAHA.108.182139.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Waeckel W, Potier L, Richer C, Roussel R, Bouby N, Alhenc-Gelas F. Pathophysiology of genetic deficiency in tissue kallikrein activity in mouse and man. Thrombosis-Haemostasis. 2013 Sept;110(3):476–83. doi:10.1160/TH12-12-0937.

    Article  CAS  PubMed  Google Scholar 

  • Werle E. Uber die Wirkung des Kallikreins auf den isolierten Darm und uber eine neue darmkontrahierende Substanz. Biochem Z. 1937;289:217–33.

    CAS  Google Scholar 

  • Zinner SH, Margolius HS, Rosner B, Keiser HR. Kass EH Familial aggregation of urinary kallikrein concentration in childhood. Am J Epidemiol. 1976;104:124–32.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. INSERM U1138, Centre de Recherche des Cordeliers, Paris-Descartes Universty, Pierre and Marie Curie University, Paris, France

    Francois Alhenc-Gelas

Authors
  1. Francois Alhenc-Gelas
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Francois Alhenc-Gelas .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Alhenc-Gelas, F. (2016). Kallikrein-K1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101810-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101810-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation