Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Rab25

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101804-1

Synonyms

Historical Background

Rab proteins including Rab25 are small GTPases belonging to Ras oncoprotein superfamily. Specifically, Rab25 is a member of the Rab11 subfamily consisting of Rab11a, Rab11b, and Rab25, which control the recycling of internalized membrane-associated moieties to the plasma membrane (Zerial and Stenmark 1993; Olkkonen and Stenmark 1997).

The human Rab25 gene is located at 1q22 encompassing 9.37 KB, from 156030940 to 156040304 (NCBI 37, August 2010), on the direct strand (HGNC: 18238; Entrez Gene: 57111; Ensembl: ENSG00000132698; OMIM: 612942; UniProtKB: P57735).

According to RefSeq, of the two reported RNA variants, only one codes for a protein (mRNA Transcript 1 which is 1138 bp linear mRNA (Accession: NM_020387.3 GI: 951232994). The other is a noncoding 942 bp linear transcribed-RNA (Accession: NR_133653.1 GI: 951235674). Predicted transcription factor binding sites in the RAB25 gene promoter include...

Keywords

Phenyl Butyrate Rab25 Gene Rab25 Expression Geranyl Geranyl Transferase GTPase Mediate Signal Transduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© Springer Science+Business Media LLC 2017

Authors and Affiliations

  1. 1.Department of Systems BiologyMD Anderson Cancer CenterHoustonUSA