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Phosphatidylinositol 4-Kinase Type II Alpha

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 145 Accesses

Synonyms

EC 2.7.1.67; Phosphatidylinositol 4-Kinase Type IIα; PI4K2A; PI4KIIα; Type II Phosphatidylinositol 4-Kinase α

Historical Background

Phosphatidylinositol 4-kinase type II α, also commonly referred to as PI4K2A or PI4KIIα, is a 54 kDa lipid kinase that catalyzes the phosphorylation of the membrane lipid phosphatidylinositol on the D4 position of its inositol headgroup to produce phosphatidylinositol 4-phosphate (PI4P). There are three other phosphatidylinositol 4-kinases expressed in most mammalian cells, PI4KB, PI4KA, and PI4KB. PI4K2A is highly homologous to the PI4KB isozyme, and together they are classified as the type II phosphatidylinositol 4-kinases (reviewed in Boura and Nencka 2015; Clayton et al. 2013). The type II phosphatidylinositol kinases differ from the type III PI4KA and PI4KB isozymes in that they are insensitive to the phosphoinositide 3-kinase inhibitors wortmannin and LY-294002, but are inhibited by low micromolar concentrations of adenosine. Furthermore,...

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Authors and Affiliations

  1. Lipid and Membrane Biology Group, Institute for Liver and Digestive Health, Division of Medicine, University College London, Floor U3, Royal Free Campus, Rowland Hill Street, London, NW3 2PF, UK

    Yassmeen Radif & Mark G. Waugh

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  1. Yassmeen Radif
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  2. Mark G. Waugh
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Correspondence to Mark G. Waugh .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Radif, Y., Waugh, M.G. (2016). Phosphatidylinositol 4-Kinase Type II Alpha. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101785-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101785-1

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  • Online ISBN: 978-1-4614-6438-9

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