Fig. 2

NMI has broad cellular functions that impact multiple cell signaling pathways and functions. Most of NMI functional impacts have been studied in the context of cancer progression. NMI functions have been linked to multiple signaling pathways, such as Wnt, TGFb, mTOR, and NFkB. NMI has been reported to activate GSK3B and inhibit mTOR signaling as well as upregulate DRAM1, both of which induce autophagic cell death. Furthermore, interactions with multiple regulators of the p53/MDM2/ARF pathway allow NMI to functionally impact cell cycle arrest. NMI is also a master regulator of the EMT program through multiple signaling nodes such as NF-ΚB, Wnt, and TGFβ. NMI interacts with proteins that involved at key regulatory nodes in each of these pathways thereby modifying their functions and ultimately mediating effects on cell death, cell cycle arrest, EMT, and ultimately cancer progression