Fig. 1

NMI has multiple functional domains reported to be important for its function. There is an N-terminal domain which has been termed as both the coiled-coil domain and IFP35 domain with highly similar homology to IFP35. The NID domain is thought to be important in protein-protein interaction and may be involved in determining cellular localization. Lastly, there are two putative RNA-binding motifs which have yet to be fully characterized. Multiple studies have determined a variety of NMI-interacting proteins most of which have been shown to influence a variety of cellular functions particularly in the context of cancer