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Rufy

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Encyclopedia of Signaling Molecules

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Synonyms

RUFY1 : FYVE-finger containing protein; Rab4a interacting protein; Rab4aip; Rabip4; RUN and FYVE domain-containing 1; ZFYVE12

RUFY2 : Denn; KIAA1537; LZ-FYVE; Rabip4R; RABIP4R; RUN and FYVE domain-containing 2; ZFYVE13

RUFY3 : RIPX; Rap2 interacting protein X; RUN and FYVE domain-containing 3; SINGAR1; Single axon-related 1; ZFYVE30

RUFY4 : RUN and FYVE domain-containing 4; ZFYVE31

Historical Background

The RUFY proteins (RUN and FYVE domain-containing protein family) have an amino-terminal RUN domain and a carboxyl-terminal FYVE domain, which associates with phosphatidylinositol 3-phosphate (PI3P) in early endosomes (Yang et al. 2002). As shown in Fig. 1, genome DNA analyses have revealed that a RUFY family consists of four members of RUFY proteins (Yoshida et al. 2010). The RUN domains, named from RPIP8, UNC-14, and NESCA proteins, might function as effectors of the small GTPase superfamily (MacDonald et al. 2004). For example, yeast two-hybrid assays for Rab binding...

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References

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Author notes

    Authors and Affiliations

    1. Department of Food Science and Nutrition, Nara Women’s University, Kita-Uoya Nishimachi, 630-8506, Nara, Japan

      Mayuko Ichimura, Atsuko Nakanishi, Yasuko Kitagishi & Satoru Matsuda

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    1. Mayuko Ichimura
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    2. Atsuko Nakanishi
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    3. Yasuko Kitagishi
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    4. Satoru Matsuda
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    Correspondence to Satoru Matsuda .

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    Editors and Affiliations

    1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

      Sangdun Choi

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    Ichimura, M., Nakanishi, A., Kitagishi, Y., Matsuda, S. (2017). Rufy. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101776-1

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    • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101776-1

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    • Print ISBN: 978-1-4614-6438-9

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