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Microtubule Affinity Regulating Kinase-4

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Encyclopedia of Signaling Molecules

Synonyms

KIAA1860; MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase like 1; MAP/microtubule affinity-regulating kinase-like 1; MARK4; MARK4 serine/threonine protein kinase; MARK4L; MARK4S; MARKL1; MARKL1L; Par-1d.

Historical Background

Microtubules (MTs) are regulated by a large number of proteins and factors. One of the classes of protein that act as a regulator of microtubules are microtubule-associated proteins (MAPs) like tau, MAP2, and MAP4 (Mandelkow and Mandelkow 1995). MAPs are widely found in the brain of vertebrates and have been studied in detail (Illenberger et al. 1996). The protein kinases like MAP/microtubule-affinity regulating kinases (MARK) phosphorylate these MAPs and regulate their activity (Drewes et al. 1997).

Microtubule-affinity regulating kinase 4 (MARK4) was first discovered in the brain of Alzheimer’s disease (AD) patients. Overexpressed MARK4 phosphorylates tau on Ser262 in the microtubule-binding domain, present...

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  1. Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India

    Neha Sami, Vijay Kumar & Md. Imtaiyaz Hassan

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  1. Neha Sami
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  2. Vijay Kumar
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  3. Md. Imtaiyaz Hassan
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Correspondence to Md. Imtaiyaz Hassan .

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  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Sami, N., Kumar, V., Hassan, M.I. (2016). Microtubule Affinity Regulating Kinase-4. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101744-1

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