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NGF

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References

  • Abbott A. One hundred years of Rita. Nature. 2009;458:564–7.

    Article  CAS  PubMed  Google Scholar 

  • Aloe L, Rocco ML, Bianchi P, Manni L. Nerve growth factor: from the early discoveries to the potential clinical use. J Transl Med. 2012;10:239.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Artim SC, Mendrola JM, Lemmon MA. Assessing the range of kinase autoinhibition mechanisms in the insulin receptor family. Biochem J. 2012;448:213–20.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bandtlow CE, Heumann R, Schwab ME, Thoenen H. Cellular localization of nerve growth factor synthesis by in situ hybridization. EMBO J. 1987;6:891–9.

    CAS  PubMed  PubMed Central  Google Scholar 

  • Basbaum AI, Bautista DM, Scherrer G, Julius D. Cellular and molecular mechanisms of pain. Cell. 2009;139:267–84.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H. NGF and proNGF: regulation of neuronal and neoplastic responses through receptor signaling. Adv Biol Regul. 2015;58:16–27.

    Article  CAS  PubMed  Google Scholar 

  • Bucci C, Alifano P, Cogli L. The role of Rab protein in neuronal cells and in the trafficking of neurotrophin receptors. Membranes. 2014;4:642–77.

    Article  PubMed  PubMed Central  Google Scholar 

  • Cunningham ME, Greene LA. A function-structure model for NGF-activated TRK. EMBO J. 1998;17:7282–93.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen KS, Nishimura MC, Armanini MP, Crowley C, Spencer SD, Phillips HS. Disruption of a single allele of the nerve growth factor gene results in atrophy of basal forebrain cholinergic neurons and memory deficits. J Neurosci. 1997;17:7288–96.

    CAS  PubMed  Google Scholar 

  • Einarsdottir E, Carlsson A, Minde J, Toolanen G, Svensson O, Solders G, Holmgren G, Holmberg D, Holmberg M. A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception. Human Mol Genet. 2004;8:799–80.

    Article  Google Scholar 

  • Hirose M, Kuroda Y, Murata E. NGF/TrkA signaling as atherapeutic target for pain. Pain Pract. 2016;16:175–82.

    Article  PubMed  Google Scholar 

  • Indo Y, Tsuruta M, Hayashida Y, Karim MA, Ohta K, Kawano T, Mitsubuchi H, Tonoki H, Awaya Y, Matsuda I. Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis. Nat Genet. 1996;13:485–8.

    Article  CAS  PubMed  Google Scholar 

  • Iulita MF, Cuello AC. Nerve growth factor metabolic dysfunction in Alzheimer’s disease and Down syndrome. Trends Pharmacol Sci. 2014;35:338–48.

    Article  CAS  PubMed  Google Scholar 

  • Khan N, Smith MT. Neurotrophins and neuropathic pain: role in pathobiology. Molecules. 2015;20:10657–88.

    Article  CAS  PubMed  Google Scholar 

  • Krock E, Currie JB, Weber MH, Ouellet JA, Stone LS, Rosenzweig DH, Haglund L. Nerve growth factor is regulated by toll-like receptor 2 in human intervertebral disks. J Biol Chem. 2016;291:3541–51.

    Article  CAS  PubMed  Google Scholar 

  • Lambiase A, Mantelli F, Sacchetti M, Rossi S, Aloe L, Bonini S. Clinical applications of NGF in occular diseases. Arch Ital Biol. 2011;149:283–92.

    PubMed  Google Scholar 

  • Landreth GE, Shooter EM. Nerve growth factor receptors on PC12 cells: ligand-induced conversion from low- to high-affinity states. Proc Natl Acad Sci USA. 1980;77:4751–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Levi-Montalcini R. Effects of mouse tumor transplantation on the nervous system. Ann NY Acad Sci. 1952;55:330–43.

    Article  CAS  PubMed  Google Scholar 

  • Levi-Montalcini R. The nerve growth factor 35 years later. Science. 1987;237:1154–62.

    Article  CAS  PubMed  Google Scholar 

  • Marlin MC, Li G. Biogenesis and function of the NGF/TrkA signaling endosome. Int Rev Cell Mol Biol. 2015;314:239–57.

    Article  PubMed  Google Scholar 

  • Miranda C, Di Virgilio M, Selleri S, Zanotti G, Pagliardini S, Pierotti MA, Greco A. Novel pathogenic mechanisms of congenital insensitivity to pain with anhidrosis genetic disorder unveiled by functional analysis of neurtrophic tyrosine receptor kinase type 1/nerve growth factor receptor mutations. J Biol Chem. 2002;277:6455–62.

    Article  CAS  PubMed  Google Scholar 

  • Mitchell DJ, Blasier KR, Jeffery ED, Ross MW, Pullikuth AK, Suo D, Park J, Smiley WR, Lo KW, Shabanowitz J, Deppmann CD, Trinidad JC, Hunt DF, Catling AD, Pfister KK. Trk activation of the ERK1/2 kinase pathway stimulates intermediate chain phosphorylation and recruits cytoplasmic dynein to signaling endosomes for retrograde axonal transport. J Neurosci. 2012;32:15495–510.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Otten U, Gadient RA. Neurotrophins and cytokimes – intermediaries between the immune and nervous systems. Int J Dev Neurosci. 1995;13:147–51.

    Article  CAS  PubMed  Google Scholar 

  • Wiesmann C, de Vos AM. Nerve growth factor: structure and function. Cell Mol Life Sci. 2001;58:748–59.

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto M, Sobue G, Yamamoto K, Terao S, Mitsuma T. Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, TrkA, TrkB, and TrkC) in the adult human peripheral nervous system and nonneural tissues. Neurochem Res. 1996;21:929–38.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Munetaka Hirose .

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Hirose, M. (2016). NGF. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101731-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101731-1

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