N-Lysine Methyltransferase SMYD
Living reference work entry
SMYD proteins are a family of histone and protein lysine methyltransferases containing a SET domain interrupted by a MYND zinc finger motif (Spellmon et al. 2015) (Fig. 1). The SET domain is evolutionally conserved in N-lysine methyltransferases and responsible for the methyltransferase activity (Sirinupong et al. 2010). The MNYD domain is a protein–protein interaction module involved in transcriptional cofactor recruitment (Spellmon et al. 2015). The SMYD family achieves the methyltransferase activity by adding methyl groups to target lysine residues using S-adenosylmethionine (AdoMet) as a donor substrate (Fig. 1). Recent studies show the SMYD protein family to be involved in cancer proliferation, epigenetic transcription regulation, the immune system, and muscle...
KeywordsEsophageal Squamous Cell Carcinoma Heart Development Methyltransferase Activity Nonhistone Protein SMYD5 Expression
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