Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

N-Lysine Methyltransferase SMYD

  • Andria Zaidan
  • Nicholas Spellmon
  • Vishakha Choudhary
  • Chunying Li
  • Zhe Yang
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101729-1

Synonyms

Historical Background

SMYD proteins are a family of histone and protein lysine methyltransferases containing a SET domain interrupted by a MYND zinc finger motif (Spellmon et al. 2015) (Fig. 1). The SET domain is evolutionally conserved in N-lysine methyltransferases and responsible for the methyltransferase activity (Sirinupong et al. 2010). The MNYD domain is a protein–protein interaction module involved in transcriptional cofactor recruitment (Spellmon et al. 2015). The SMYD family achieves the methyltransferase activity by adding methyl groups to target lysine residues using S-adenosylmethionine (AdoMet) as a donor substrate (Fig. 1). Recent studies show the SMYD protein family to be involved in cancer proliferation, epigenetic transcription regulation, the immune system, and muscle...

Keywords

Zinc Migration Arthritis Estrogen Leukemia 
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Andria Zaidan
    • 1
  • Nicholas Spellmon
    • 1
  • Vishakha Choudhary
    • 1
  • Chunying Li
    • 2
  • Zhe Yang
    • 3
  1. 1.DetroitUSA
  2. 2.AtlantaUSA
  3. 3.Department of Biochemistry and Molecular BiologyWayne State University School of MedicineDetroitUSA