Living reference work entry
Sirtuins are a conserved family of proteins with homology to silent information regulator 2 (Sir2) of Saccharomyces cerevisiae, initially identified as genetic silencing factors (Rine et al. 1979) and later found to extend longevity in yeast, worms, and flies. Subsequent studies showed that Sir2 is a NAD +-dependent deacetylase that targets both histones and nonhistone proteins (Imai et al. 2000) and it also possesses mono-ADP-ribosyltransferase activity, functions that are highly conserved during evolution. Importantly, NAD +-dependent deacetylation by Sir2 was later linked to lifespan extension associated with calorie restriction (Lin et al. 2000). Mammals have seven homologs of Sir2 (SIRT1–SIRT7), of which SIRT1 is the closest mammalian homolog in structure and function to yeast Sir2. All sirtuins share a conserved NAD +-binding site and a catalytic core domain of ∼275...
KeywordsWhite Adipose Tissue Nuclear Export Signal SIRT2 Expression SIRT2 Activity SIRT2 Overexpression
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