MAPK Interacting Protein Kinase 1 and 2 (Mnk1 and Mnk2)
Living reference work entry
The MAPK interacting protein kinases 1 and 2 were identified as a part of a screen to identify novel proteins that can be phosphorylated by extracellular regulated kinase (Erk) (Fukunaga and Hunter 1997). This screen identified Mnk1 as an Erk2 substrate. Additionally Mnk1 was found to be phosphorylated by the p38 MAPK and the Erk kinase but not by c-Jun N-terminal kinases/stress-activated protein kinases (JNK/SAPK) (Fukunaga and Hunter 1997). Stimulation with 12-O-tetradecanoylphorbol-13-acetate, fetal calf serum, anisomycin, UV irradiation, tumor necrosis factor-alpha, interleukin-1beta, or osmotic shock also resulted in phosphorylation of Mnk1 in an Erk and/or p38-dependent manner (Fukunaga and Hunter 1997). Another study utilizing a two-hybrid screen approach to identify novel Erk2 substrates identified Mnk1 as an Erk2 target (Waskiewicz et al. 1997)....
KeywordsActivation Loop Nuclear Export Signal High Basal Activity eIF4E Phosphorylation Erk2 Substrate
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