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MAP/Microtubule Affinity-Regulating Kinase

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Encyclopedia of Signaling Molecules

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Synonyms

MARK1: EMK3, hPAR-1c, KIAA1477; MARK2: EMK1, hPAR-1b; MARK3: EMK3, hPAR-1a, C-TAK1, KP78; MARK4: MARKL1, hPAR-1d, KIAA1860

Historical Background

Microtubule-associated protein (MAP)/microtubule affinity-regulating kinase [MARK] was first identified for its role in phosphorylating tau, a MAP implicated in Alzheimer’s disease [AD] (Drewes et al. 1995). Following this discovery, four MARK isoforms were identified in humans and rodents, all of which phosphorylate tau, MAP2, and MAP4 (Drewes et al. 1995; Illenberger et al. 1996; Drewes 2004). Phosphorylation of MAPs causes them to dissociate from microtubules [MTs] leading to MT destabilization (Drewes et al. 1997; Drewes et al. 1998). Tau has been the subject of intensive studies because its phosphorylation is elevated in the AD brain. Since MARK phosphorylates tau, it is a candidate of prime interest as a possible therapeutic target in treating AD and other brain disorders (Drewes 2004; Naz et al. 2013). MARK has also been found...

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Acknowledgments

This work was supported by grants from the National Institutes of Health, NICHD, R01 HD056034 to C.Y.C., and U54 HD029990 Project 5 to C.Y.C.

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Authors and Affiliations

  1. The Mary M. Wohlford Laboratory for Male Contraceptive Research, Center for Biomedical Research, Population Council, 1230 York Ave, New York, NY, 10065, USA

    Elizabeth Tang & C. Yan Cheng

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  1. Elizabeth Tang
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  2. C. Yan Cheng
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Correspondence to C. Yan Cheng .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Tang, E., Cheng, C.Y. (2016). MAP/Microtubule Affinity-Regulating Kinase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101717-1

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