Fig. 3

MASP2 gene and MASP-2 and MAp19 protein structures. Exons coding protein domains and these regions in the protein structure are shown with the same color. The regulatory domains are indicated by blue (CUB1 and EGF) and green colors (CUB2, CCP1, and CCP2). The MASP-2 serine protease region is in orange and the -terminal domain of MAp19 in red. MASP mannose-binding lectin-associated serine protease, MAp19 mannose-binding lectin-associated protein of 19 kDa, CUB C1r/C1s, Uegf, and bone morphogenetic protein, EGF epidermal growth factor, CCP complement control protein. Exons are drawn to scale and introns are truncated