Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

MAP4K3 (GLK)

  • Huai-Chia Chuang
  • Tse-Hua Tan
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101713-1

Synonyms

Historical Background

The serine/threonine kinase GCK-like kinase (GLK) is first identified by screening a human skeletal muscle cDNA library using degenerate oligonucleotide PCR primers (Diener et al. 1997). The nucleotide sequence of GLK encodes an open reading frame of 894 amino acids with a calculated molecular mass of 100 kDa. GLK shares 57% amino acid identity with MAP4K2 (also named germinal center kinase; GCK) and 49% amino acid identity with MAP4K1 (also named hematopoietic progenitor kinase 1 (HPK1)) (Hu et al. 1996; Diener et al. 1997). Thus, GLK is classified as a member of the MAP kinase kinase kinase kinase (MAP4K) family and also named MAP4K3. The MAP4K3/GLK protein contains a conserved N-terminal kinase domain, three proline-rich regions, and a conserved C-terminal citron homology domain (Fig. 1). Three splice variants of human...

Keywords

Systemic Lupus Erythematosus Experimental Autoimmune Encephalomyelitis Experimental Autoimmune Encephalomyelitis Induction AOSD Patient Autoimmune Disease Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Immunology Research Center, National Health Research InstitutesZhunanTaiwan