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Encyclopedia of Signaling Molecules pp 1–6Cite as

NEDD4–2

  • Living reference work entry
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Synonyms

NEDD4L; NEDL3; KIAA0439; hNEDD4-2

Historical Background

NEDD4–2 (neural precursor cell expressed, developmentally downregulated 4-like) encoded by the Nedd4L gene, belongs to the NEDD4 family of ubiquitin protein ligases. NEDD4 family members are HECT-type ubiquitin ligases (E3) that act at the final step of the ubiquitin cascade to accept ubiquitin from a ubiquitin-conjugating enzyme (E2) and transfer it to their cognate substrates. Ubiquitination of a protein often targets it for degradation; however it may also affect protein localization, trafficking, and recognition by signaling or regulatory complexes. The other members of the NEDD4 family include NEDD4, ITCH, SMURF1, SMURF2, WWP1, WWP2, NEDL1, and NEDL2 (Rotin and Kumar 2009).

NEDD4–2 (originally submitted in the database as mouse KIAA0439 or human NEDD4Lgene) is most closely related to the founding member, NEDD4, which was originally identified in the early embryonic central nervous system as a developmentally...

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References

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Authors and Affiliations

  1. Centre for Cancer Biology, University of South Australia, SA, 5001, Adelaide, Australia

    Tanya Lynn Henshall & Sharad Kumar

Authors
  1. Tanya Lynn Henshall
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  2. Sharad Kumar
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Corresponding author

Correspondence to Sharad Kumar .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Henshall, T.L., Kumar, S. (2016). NEDD4–2. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101704-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101704-1

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  • Online ISBN: 978-1-4614-6438-9

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