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Dual-specificity Protein Phosphatases

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Encyclopedia of Signaling Molecules

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Synonyms

DSP; Dual specificity protein phosphatase; Mammalian class I dual-specificity cysteine-based phosphatase (DSP); MAPK phosphatase; MKP; Dual-specificity Protein Tyrosine Phosphatase (PTP); DSPase

Historical Background

In the 1980s, the regulatory role of protein phosphorylation in influencing cell growth, differentiation, and division was found to be mediated by the coordinated action of protein kinases and phosphatases. One particular family of protein ser/thr kinases, known as MAPKs, play key mitogen-activated protein kinases (MAPKs) play key regulatory roles by responding to various extracellular and intracellular stimuli and changes. By phosphorylating downstream targets including protein kinases and transcription factors, activated MAPKs regulate the transcription of MAPK-regulated genes, translation of proteins, and protein activity. The basic physiological processes of the cell growth and survival including cell division, differentiation, metabolism, motility,...

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Authors and Affiliations

  1. College of Natural and Health Sciences, Southeastern University, 1000 Longfellow Boulevard, Lakeland, FL, 33801, USA

    Sheila Prabhakar

  2. Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL, 61605, USA

    Swapna Asuthkar, Andrew J. Tsung & Kiran K. Velpula

  3. Department of Neurosurgery, University of Illinois College of Medicine at Peoria, One Illini Drive, Peoria, IL, 61605, USA

    Andrew J. Tsung & Kiran K. Velpula

Authors
  1. Sheila Prabhakar
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  2. Swapna Asuthkar
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  3. Andrew J. Tsung
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  4. Kiran K. Velpula
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Corresponding author

Correspondence to Kiran K. Velpula .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Prabhakar, S., Asuthkar, S., Tsung, A.J., Velpula, K.K. (2016). Dual-specificity Protein Phosphatases. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101694-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101694-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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