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Kv1.1

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

AEMK; EA1; Episodic ataxia with myokymia; HBK1; HUK1; HUKI; Kca1-1; Kcna1; Kv1.1; MBK1; Mk-1; MK1; Potassium voltage-gated channel; RBK1; Shak; Shaker-related subfamily, member 1

Historical Background

The discovery of the voltage-dependent potassium conductance by Hodgkin and Huxley (Hodgkin and Huxley 1953) stimulated series of biophysical and molecular biological studies, which led to cloning and identification of the voltage-gated K+ channels with their characterization. The pioneering research by Jan et al. (1977) showing that the Shaker mutant phenotype in drosophila can be induced in wild type by the potassium channel blocker 4-AP was a first step towards isolation of KV1 channel proteins. Cloning of the Drosophila Shaker channels (Papazian et al. 1987; Tempel et al. 1987) was followed by purification of the mammalian ortholog Kv1.1, revealing very high degree of their conservation (Tempel et al. 1988). It was subsequently shown that the highly conserved N-terminal...

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Authors and Affiliations

  1. Institute for Biological and Medical Imaging, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany

    Saak V. Ovsepian

  2. Munich School of Bioengineering, Technical University Munich, 81675, Munich, Germany

    Saak V. Ovsepian

  3. International Centre for Neurotherapeutics, Dublin City University, Dublin, 9, Ireland

    Saak V. Ovsepian & J. Oliver Dolly

  4. Division of Neurobiology, Department of Biology II, Ludwig-Maximilians-University of Munich,, Planegg-Martinsried, Germany

    Conny Kopp-Scheinpflug

  5. Institute of Radiation Biology, Helmholtz Zentrum Munich, German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany

    Valerie B. O’Leary

Authors
  1. Saak V. Ovsepian
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  2. Conny Kopp-Scheinpflug
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  3. Valerie B. O’Leary
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  4. J. Oliver Dolly
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Corresponding authors

Correspondence to Saak V. Ovsepian or J. Oliver Dolly .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Ovsepian, S.V., Kopp-Scheinpflug, C., O’Leary, V.B., Oliver Dolly, J. (2016). Kv1.1. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101677-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101677-1

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