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Growth Hormone Releasing Hormone (GHRH)

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References

  • Allen DB, Backeljauw P, Bidlingmaier M, Biller BM, Boguszewski M, Burman P, et al. GH safety workshop position paper: a critical appraisal of recombinant human GH therapy in children and adults. Eur J Endocrinol. 2016;174:P1–9. doi:10.1530/EJE-15-0873.

    Article  CAS  PubMed  Google Scholar 

  • Baker LD, Barsness SM, Borson S, Merriam GR, Friedman SD, Craft S, et al. Effects of growth hormone-releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial. Arch Neurol. 2012;69:1420–9. doi:10.1001/archneurol.2012.1970.

    Article  PubMed  PubMed Central  Google Scholar 

  • Doga M, Bonadonna S, Burattin A, Giustina A. Ectopic secretion of growth hormone-releasing hormone (GHRH) in neuroendocrine tumors: relevant clinical aspects. Ann Oncol. 2001;12(Suppl 2):S89–94.

    Article  PubMed  Google Scholar 

  • Frohman LA, Nernardis LL, Kant KJ. Hypothalamic stimulation of growth hormone secretion. Science. 1968;162:580–2.

    Article  CAS  PubMed  Google Scholar 

  • Frohman LA, Szabo M, Berelowitz M, Stachura ME. Partial purification and characterization of a peptide with growth hormone-releasing activity from extrapituitary tumors in patients with acromegaly. J Clin Invest. 1980;65:43–54. doi:10.1172/JCI109658.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Gubler U, Monahan JJ, Lomedico PT, Bhatt RS, Collier KJ, Hoffman BJ, et al. Cloning and sequence analysis of cDNA for the precursor of human growth hormone-releasing factor, somatocrinin. Proc Natl Acad Sci U S A. 1983;80:4311–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kanashiro-Takeuchi RM, Szalontay L, Schally AV, Takeuchi LM, Popovics P, Jaszberenyi M, et al. New therapeutic approach to heart failure due to myocardial infarction based on targeting growth hormone-releasing hormone receptor. Oncotarget. 2015;6:9728–39. doi:10.18632/oncotarget.3303.

    Article  PubMed  PubMed Central  Google Scholar 

  • Lin-Su K, Wajnrajch MP. Growth hormone releasing hormone (GHRH) and the GHRH receptor. Rev Endocr Metab Disord. 2002;3:313–23.

    Article  CAS  PubMed  Google Scholar 

  • Margioris AN, Brockmann G, Bohler Jr HC, Grino M, Vamvakopoulos N, Chrousos GP. Expression and localization of growth hormone-releasing hormone messenger ribonucleic acid in rat placenta: in vitro secretion and regulation of its peptide product. Endocrinology. 1990;126:151–8. doi:10.1210/endo-126-1-151.

    Article  CAS  PubMed  Google Scholar 

  • Mayo KE, Vale W, Rivier J, Rosenfeld MG, Evans RM. Expression-cloning and sequence of a cDNA encoding human growth hormone-releasing factor. Nature. 1983;306:86–8.

    Article  CAS  PubMed  Google Scholar 

  • Mayo KE, Godfrey PA, Suhr ST, Kulik DJ, Rahal JO. Growth hormone-releasing hormone: synthesis and signaling. Recent Prog Horm Res. 1995;50:35–73.

    CAS  PubMed  Google Scholar 

  • Obal Jr F, Krueger JM. GHRH and sleep. Sleep Med Rev. 2004;8:367–77. doi:10.1016/j.smrv.2004.03.005.

    Article  PubMed  Google Scholar 

  • Reichlin S. Growth hormone content of pituitaries from rats with hypothalamic lesions. Endocrinology. 1961;69:225–30. doi:10.1210/endo-69-2-225.

    Article  CAS  PubMed  Google Scholar 

  • Romero MJ, Lucas R, Dou H, Sridhar S, Czikora I, Mosieri EM, et al. Role of growth hormone-releasing hormone in dyslipidemia associated with experimental type 1 diabetes. Proc Natl Acad Sci U S A. 2016;113:1895–900. doi:10.1073/pnas.1525520113.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schally AV, Steelman SL, Bowers CY. Effect of hypothalamic extracts on release of growth hormone in vitro. Proc Soc Exp Biol Med. 1965;119:208–12.

    Article  CAS  PubMed  Google Scholar 

  • Schally AV, Varga JL, Engel JB. Antagonists of growth-hormone-releasing hormone: an emerging new therapy for cancer. Nat Clin Pract Endocrinol Metab. 2008;4:33–43. doi:10.1038/ncpendmet0677.

    Article  CAS  PubMed  Google Scholar 

  • Steyn FJ. Nutrient sensing overrides somatostatin and growth hormone-releasing hormone to control pulsatile growth hormone release. J Neuroendocrinol. 2015;27:577–87. doi:10.1111/jne.12278.

    Article  CAS  PubMed  Google Scholar 

  • Steyn FJ, Tolle V, Chen C, Epelbaum J. Neuroendocrine regulation of growth hormone secretion. Compr Physiol. 2016;6:687–735. doi:10.1002/cphy.c150002.

    Article  PubMed  Google Scholar 

  • Thorner MO. The discovery of growth hormone-releasing hormone. J Clin Endocrinol Metab. 1999;84:4671–6. doi:10.1210/jcem.84.12.6210.

    CAS  PubMed  Google Scholar 

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Correspondence to Frederik J. Steyn .

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Steyn, F.J. (2016). Growth Hormone Releasing Hormone (GHRH). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101674-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101674-1

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