Inhibitor of KappaB
The transcriptional factor NF-κB – a key regulator of cellular events such as cell growth, immune response, and cell survival – was first identified by Dr. David Baltimore’s group (Sen and Baltimore 1986). Inhibitor of kappaB (IκB) can form a complex with NF-κB and control these events. IκB family proteins harbor an ankyrin (ANK) repeat domain, a core motif of NF-κB binding, which was first identified in the cell-cycle gene sequences of yeast and Drosophila in 1987 (Breeden and Nasmyth 1987). IκB family members have been found to have conserved ANK repeat domains, including β-strand and α-helix repeat sequences. On the basis of extensive studies, nine IκB family proteins harboring ANK repeats have been identified, and these IκB proteins are...
KeywordsChronic Lymphocytic Leukemia Experimental Autoimmune Encephalomyelitis Control Gene Regulation
- Kobayashi S, Hara A, Isagawa T, Manabe I, Takeda K, MaruYama T. The nuclear IkappaB family protein IkappaBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model. PLoS One. 2014;9:e110838. doi:10.1371/journal.pone.0110838.CrossRefPubMedPubMedCentralGoogle Scholar