Inhibitor of KappaB
The transcriptional factor NF-κB – a key regulator of cellular events such as cell growth, immune response, and cell survival – was first identified by Dr. David Baltimore’s group (Sen and Baltimore 1986). Inhibitor of kappaB (IκB) can form a complex with NF-κB and control these events. IκB family proteins harbor an ankyrin (ANK) repeat domain, a core motif of NF-κB binding, which was first identified in the cell-cycle gene sequences of yeast and Drosophila in 1987 (Breeden and Nasmyth 1987). IκB family members have been found to have conserved ANK repeat domains, including β-strand and α-helix repeat sequences. On the basis of extensive studies, nine IκB family proteins harboring ANK repeats have been identified, and these IκB proteins are...
KeywordsLeukemia Cytosol Encephalomyelitis
- Kobayashi S, Hara A, Isagawa T, Manabe I, Takeda K, MaruYama T. The nuclear IkappaB family protein IkappaBNS influences the susceptibility to experimental autoimmune encephalomyelitis in a murine model. PLoS One. 2014;9:e110838. doi:10.1371/journal.pone.0110838.CrossRefPubMedPubMedCentralGoogle Scholar