Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

G Protein–Coupled Receptor Kinase

  • Michael Steury
  • Narayanan Parameswaran
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101633-1

Synonyms

Historical Background

G protein–coupled receptor kinases (GRKs) represent a family of seven serine/threonine kinases that, based on their sequence similarities, can further be broken down into three subfamilies. These subfamilies include: GRK1, composed of GRK1 (rhodopsin kinase) and GRK7 (cone opsin kinase); GRK2, including GRK2 and GRK3; and GRK4, made up of GRK4, 5, and 6. These kinases were initially identified for their ability to phosphorylate G protein–coupled receptors (GPCRs). Phosphorylation of the receptor by GRKs leads to the recruitment of β-arrestins and consequently desensitization and internalization of the receptor. This internalization can then lead to additional signaling cascades. Furthermore, it has recently become evident that individual GRKs can interact in a kinase dependent or independent manner with nonreceptor substrates and influence a variety of physiological functions and pathologies.

Evolutionarily, GRKs are present in...

Keywords

Dopamine Receptor Receptor Desensitization Pleckstrin Homology Domain Night Blindness Palmitoylation Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of PhysiologyMichigan State UniversityEast LansingUSA