Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

LGR4 (Leucine-Rich Repeat G-Protein Coupled Receptor 4)

Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101612-1


Historical Background

Leucine-rich repeat G-protein-coupled receptors (LGRs) are a class of G-protein-coupled receptors characterized by a large extracellular domain containing several leucine-rich repeats (LRR) (Van Loy et al. 2008). According to phylogenetic analysis, there are three known LGR subgroups in mammals (Van Loy et al. 2008). Subtype A consists of receptors for glycoprotein including follicle-stimulating hormone (FSH), luteinizing hormone (LH), and chorionic gonadotropin (CG). All of which are dimeric proteins composed of a common α-subunit and a hormone-specific β-subunit (Van Loy et al. 2008). In mammals, subtype C refers to LGRs 7–8. This type of LGR receptors contains a unique N-terminal low-density lipoprotein (LDL) motif (Van Loy et al. 2008). Subtype B is composed of three mammalian receptors LGR4–6 characterized by the presence of 13–18 leucine-rich repeats (LRRs) (Van Loy et al. 2008). Many...


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This work was supported by grants from the National Natural Science Foundation of China (81330010, 81390354) and American Diabetes Association grant #1-13-BS-225.


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Authors and Affiliations

  1. 1.Department of Physiology and Pathophysiology, School of Basic Medical SciencesPeking University Health Science CenterBeijingChina
  2. 2.Department of SurgeryUniversity of Michigan Medical CenterAnn ArborUSA