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Fascin

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 160 Accesses

Synonyms

55-kDa actin-bundling protein; Fascin; Fascin homolog1, actin-bundling protein (Strongylocentrotus purpuratus); FSCN1; p55; Singed-like (fascin homolog, sea urchin); Singed-like protein

Historical Background

Fascin is a monomeric actin-bundling protein that was first isolated from sea urchin coelomocytes, later isolated as 55-kDa actin-bundling protein from HeLa cells (see for review, Jayo and Parsons 2010). It has a molecular weight of 55–58,000 kDa and makes extensive actin bundles in vitro with uniform polarity. The cloning of sea urchin fascin by Bryan et al. in 1993 revealed that fascin is homologous to the Drosophila singed gene product (Bryan et al. 1993). In 1994, Duh et al. and Holthuis et al. isolated human and Xenopus homologs of fascin, respectively (Duh et al. 1994; Holthuis et al. 1994). The sequence analyses revealed that fascin proteins form a unique family of actin-bundling proteins, sharing no apparent homology with nonfascin actin-bundling proteins...

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References

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Authors and Affiliations

  1. Department of Molecular Biology & Biochemistry, Nelson Labs, Rutgers University, 604 Allison Rd, Piscataway, NJ, 08854, USA

    Shigeko Yamashiro & Fumio Matsumura

Authors
  1. Shigeko Yamashiro
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  2. Fumio Matsumura
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Correspondence to Shigeko Yamashiro .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Yamashiro, S., Matsumura, F. (2016). Fascin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101606-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101606-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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