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Encyclopedia of Signaling Molecules pp 1–8Cite as

ΔFosB

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Synonyms

FosB short form

Historical Background

ΔFosB is encoded by the FosB gene and shares homology with other Fos family transcription factors, which include c-Fos, FosB, Fra1, and Fra2. All Fos family proteins heterodimerize with Jun family proteins (c-Jun, JunB, or JunD) to form active AP1 (activator protein-1) transcription factors that bind to AP1 sites (consensus sequence: TGAC/GTCA) present in the promoters of certain genes to regulate their transcription. The genes encoding Fos family proteins are termed immediate early genes based on their rapid induction in a cell-type-specific manner in diverse tissues, including neurons in the intact brain, in response to a wide range of acute stimuli. All of these Fos family proteins, however, and their mRNA transcripts are highly unstable, which causes them to return to basal levels within hours of the stimulus. ΔFosB is unique among Fos family proteins in exhibiting a very different induction profile (Hope et al. 1994; Hiroi et al. 1997...

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References

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Authors and Affiliations

  1. Fishberg Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Eric J. Nestler

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  1. Eric J. Nestler
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Correspondence to Eric J. Nestler .

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Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Nestler, E.J. (2016). ΔFosB. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101602-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101602-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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