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Epac

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

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Synonyms

cAMP-GEFI; cAMP-GEFII; cAMP-regulated guanine nucleotide exchange factor; Exchange factor directly activated by cAMP; Exchange protein directly activated by cAMP (Epac); Exchange protein directly activated by cAMP 1 (Epac1); Exchange protein directly activated by cAMP 2 (Epac2); Rap guanine-nucleotide exchange factor (GEF); Rap guanine nucleotide exchange factor 3 (Rapgef3); Rap guanine nucleotide exchange factor 4 (Rapgef4); Rap1 guanine-nucleotide-exchange factor directly activated by cAMP

Historical Background

Eukaryotic cells respond to a wide range of extracellular signals such as growth factors, hormones, and neurotransmitters through the generation of intracellular second messengers. One of the most studied second messenger, cyclic adenosine 3′–5′-monophosphate (cAMP), regulates many cellular events, including secretion, differentiation, migration, and apoptosis. cAMP is produced from adenosine triphosphate (ATP) by adenylyl cyclase (AC) in response to Gαs-coupled G...

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References

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Acknowledgments

F. Lezoualc’h was supported by grants from Institut National de la Santé et de la Recherche Médicale, Fondation pour la Recherche Médicale (Programme “Equipes FRM 2016”, DEQ20160334892), Fondation de France (00066331) and Université de Toulouse.

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Authors and Affiliations

  1. Inserm, UMR-1048, Institut des Maladies Métaboliques et Cardiovasculaires, Toulouse, France

    Caroline Conte & Frank Lezoualc’h

  2. Université de Toulouse – Paul Sabatier, Toulouse, France

    Caroline Conte & Frank Lezoualc’h

Authors
  1. Caroline Conte
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  2. Frank Lezoualc’h
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Corresponding author

Correspondence to Frank Lezoualc’h .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Conte, C., Lezoualc’h, F. (2016). Epac. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101595-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101595-1

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  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

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