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RBR E3 Ubiquitin Ligases

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Encyclopedia of Signaling Molecules

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Synonyms

RING-between-RING E3 ubiquitin ligase; RING-BRcat-Rcat E3 ubiquitin ligase; TRIAD

Human RBR E3 Ubiquitin Ligase Family Members

ANKIB1 (KIAA0708/KIAA1386), ARA54 (TRIAD2/RNF14/HFB30/HRIHFB2038), Dorfin (IBRDC3/RNF19), HHARI (Ariadne-1/H7-AP2/MOP-2/ARIH1), HOIL-1 (RBCK1/C20orf18/RNF54/XAP3/XAP4), HOIP (PAUL/RNF31/ZIBRA), Parc (Cullin-9/CUL-9, H7AP1), Parkin (Prkn/Park2), RNF144A (KIAA0161)/UBCE7IP4), RNF144B (p53RFP/PIR2/IBRDC2), RNF19B (IBRDC3/NKLAM), RNF217 (C6orf172/IBRDC1), TRIAD1 (Ariadne-2), TRIAD3 (RNF216/ZIN).

Historical Background

The RBR E3 ligase family, comprised of two conserved zinc-binding RING-like domains surrounding a novel zinc-binding motif, was originally identified independently by two research groups. This newly recognized zinc-binding motif was named DRIL (double RING finger linked), as it was exclusively found between two conserved RING-like sequences, and the supradomain was named TRIAD (two RING fingers and a DRIL) (van der Reijden et al. 1999)....

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References

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Author notes

    Authors and Affiliations

    1. Gustaf H. Carlson School of Chemistry and Biochemistry, Clark University, 950 Main St, 01610, Worcester, MA, USA

      Steven A. Beasley, Yaya Wang & Donald E. Spratt

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    1. Steven A. Beasley
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    2. Yaya Wang
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    3. Donald E. Spratt
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    Correspondence to Donald E. Spratt .

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    Editors and Affiliations

    1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

      Sangdun Choi

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    Beasley, S.A., Wang, Y., Spratt, D.E. (2016). RBR E3 Ubiquitin Ligases. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101592-1

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    • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101592-1

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