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Cycloxygenase

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 86 Accesses

Synonyms

PHS; Prostaglandin synthase; Prostaglandin synthetase; Prostaglandin-endoperoxide synthase; PTGS

Historical Background

Although the Ebers papyrus from ancient Egypt (1850 BC), the oldest preserved medical text, includes the first record of the use of plant remedies from the bark of poplar trees for the treatment of pain and fever, it was not until 1800s that the antipyretic and analgesic effects of willow bark was known to be originated from the active component, salicin. Later on, Kolbe and Lautemann developed a highly efficient method for the synthesis of salicylic acid from phenol. In 1897, “aspirin” was developed by Bayer Company and distributed in the general population as an antiseptic and antipyretic. Despite the wide use of nonsteroidal anti-inflammatory drug (NSAID) over the last century, the mechanism of action was not fully understood until 1971, when Vane, an awardee of Nobel Prize in physiology and medicine in 1982, showed that NSAIDs inhibited the enzyme activity...

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References

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do, 13620, South Korea

    Dong Hoon Suh

  2. Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea

    Yong Sang Song

Authors
  1. Dong Hoon Suh
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  2. Yong Sang Song
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Corresponding author

Correspondence to Yong Sang Song .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Suh, D.H., Song, Y.S. (2016). Cycloxygenase. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101577-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101577-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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