Skip to main content
SpringerLink
Log in

Epsin

  • Living reference work entry
  • First Online:
Book cover Encyclopedia of Signaling Molecules

  • 132 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

References

  • Aguilar RC, Longhi SA, Shaw JD, Yeh LY, Kim S, Schon A, et al. Epsin N-terminal homology domains perform an essential function regulating Cdc42 through binding Cdc42 GTPase-activating proteins. Proc Natl Acad Sci USA. 2006;103(11):4116–21.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brady RJ, Damer CK, Heuser JE, O’Halloran TJ. Regulation of Hip1r by epsin controls the temporal and spatial coupling of actin filaments to clathrin-coated pits. J Cell Sci. 1 Nov 2010;123(Pt 21):3652–3661.

    Google Scholar 

  • Chang B, Tessneer KL, McManus J, Liu X, Hahn S, Pasula S, Wu H, Song H, Chen Y, Cai X, Dong Y, Brophy ML, Rahman R, Ma JX, Xia L, Chen H. Epsin is required for Dishevelled stability and Wnt signalling activation in colon cancer development. Nat Commun. 16 Mar 2015;6:6380. doi: 10.1038/ncomms7380.

    Google Scholar 

  • Chen C, Zhuang X. Epsin 1 is a cargo-specific adaptor for the clathrin-mediated endocytosis of the influenza virus. Proc Natl Acad Sci U S A. 2008;105(33):11790–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Chen H, Fre S, Slepnev VI, Capua MR, Takei K, Butler MH, et al. Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. Nature. 1998;394(6695):793–7.

    Article  CAS  PubMed  Google Scholar 

  • Chen B, Dores MR, Grimsey N, Canto I, Barker BL, Trejo J. AP-2 and epsin-1 mediate protease-activated receptor-1 internalization via phosphorylation- and ubiquitination-dependent sorting signals. J Biol Chem. 2011;286(47):40760–70.

    Google Scholar 

  • Coon BG, Burgner J, Camonis JH, Aguilar RC. The epsin family of endocytic adaptors promotes fibrosarcoma migration and invasion. J Biol Chem. 2010;285(43):33073–81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Csikós G, Lippai M, Lukácsovich T, Juhász G, Henn L, Erdélyi M, et al. A novel role for the Drosophila epsin (lqf): involvement in autophagy. Autophagy. 2009;5(5):636–48.

    Article  PubMed  Google Scholar 

  • Ford MG, Mills IG, Peter BJ, Vallis Y, Praefcke GJ, Evans PR, et al. Curvature of clathrin-coated pits driven by epsin. Nature. 2002;419(6905):361–6.

    Article  CAS  PubMed  Google Scholar 

  • Goh LK, Huang F, Kim W, Gygi S, Sorkin A. Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor. J Cell Biol. 2010;189(5):871–83.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Henry AG, Hislop JN, Grove J, Thorn K, Marsh M, von Zastrow M. Regulation of endocytic clathrin dynamics by cargo ubiquitination. Dev Cell. 11 Sep 2012;23(3):519–532.

    Google Scholar 

  • Kang YL, Yochem J, Bell L, Sorensen EB, Chen L, Conner SD. Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Mol Biol Cell. Feb 2013;24(3):308–318.

    Google Scholar 

  • Liu X, Pasula S, Song H, Tessneer KL, Dong Y, Hahn S, Yago T, Brophy ML, Chang B, Cai X, Wu H, McManus J, Ichise H, Georgescu C, Wren JD, Griffin C, Xia L, Srinivasan RS, Chen H. Temporal and spatial regulation of epsin abundance and VEGFR3 signaling are required for lymphatic valve formation and function. Sci Signal. 14 Oct 2014;7(347):ra97.

    Google Scholar 

  • Meloty-Kapella L, Shergill B, Kuon J, Botvinick E, Weinmaster G. Notch ligand endocytosis generates mechanical pulling force dependent on dynamin, epsins, and actin. Dev Cell. 12 Jan 2012;22(6):1299–1312.

    Google Scholar 

  • Messa M, Fernández-Busnadiego R, Sun EW, Chen H, Czapla H, Wrasman K, Wu Y, Ko G, Ross T, Wendland B, De Camilli P. Epsin deficiency impairs endocytosis by stalling the actin-dependent invagination of endocytic clathrin-coated pits. Elife. 13 Aug 2014;3:e03311. 10.7554/eLife.03311.

    Google Scholar 

  • Mettlen M, Stoeber M, Loerke D, Antonescu CN, Danuser G, Schmid SL. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol Biol Cell. 2009;20(14):3251–60.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mukherjee D, Coon BG, Edwards DF, Hanna CB, Longhi SA, McCaffery JM, et al. The yeast endocytic protein Epsin 2 functions in a cell-division signaling pathway. J Cell Sci. 2009;122(14):2453–63.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pasula S, Cai X, Dong Y, Messa M, McManus J, Chang B, Liu X, Zhu H, Mansat RS, Yoon SJ, Hahn S, Keeling J, Saunders D, Ko G, Knight J, Newton G, Luscinskas F, Sun X, Towner R, Lupu F, Xia L, Cremona O, De Camilli P, Min W, Chen H. Endothelial epsin deficiency decreases tumor growth by enhancing VEGF signaling. J Clin Invest. Dec 2012;122(12):4424–4438.

    Google Scholar 

  • Rosenthal JA, Chen H, Slepnev VI, Pellegrini L, Salcini AE, Di Fiore PP, et al. The epsins define a family of proteins that interact with components of the clathrin coat and contain a new protein module. J Biol Chem. 1999;274(48):33959–65.

    Article  CAS  PubMed  Google Scholar 

  • Sen A, Madhivanan K, Mukherjee D, Aguilar RC. The epsin protein family: coordinators of endocytosis and signaling. Biomol Concepts. Apr 2012;3(2):117–126.

    Google Scholar 

  • Sorkina T, Miranda M, Dionne KR, Hoover BR, Zahniser NR, Sorkin A. RNA interference screen reveals an essential role of Nedd4-2 in dopamine transporter ubiquitination and endocytosis. J Neurosci. 2006;26(31):8195–205.

    Article  CAS  PubMed  Google Scholar 

  • Sorrentino V, Nelson JK, Maspero E, Marques AR, Scheer L, Polo S, Zelcer N. The LXR-IDOL axis defines a clathrin-, caveolae-, and dynamin-independent endocytic route for LDLR internalization and lysosomal degradation. J Lipid Res. Aug 2013;54(8):2174–2184.

    Google Scholar 

  • Sugiyama S, Kishida S, Chayama K, Koyama S, Kikuchi A. Ubiquitin-interacting motifs of Epsin are involved in the regulation of insulin-dependent endocytosis. J Biochem. 2005;137(3):355–64.

    Article  CAS  PubMed  Google Scholar 

  • Szymanska M, Fosdahl AM, Raiborg C, Dietrich M, Liestøl K, Stang E, Bertelsen V. Interaction with epsin 1 regulates the constitutive clathrin-dependent internalization of ErbB3. Biochim Biophys Acta. Jun 2016;1863(6 Pt A):1179–1188.

    Google Scholar 

  • Wang H, Traub LM, Weixel KM, Hawryluk MJ, Shah N, Edinger RS, et al. Clathrin-mediated endocytosis of the epithelial sodium channel. Role of epsin. J Biol Chem. 2006;281(20):14129–35.

    Article  CAS  PubMed  Google Scholar 

  • Wendland B. Epsins: adaptors in endocytosis? Nat Rev Mol Cell Biol. 2002;3(12):971–7.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Biological Sciences, Purdue University, 201 S. University st, West Lafayette, IN, 47907, USA

    R. Claudio Aguilar

Authors
  1. R. Claudio Aguilar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to R. Claudio Aguilar .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Aguilar, R.C. (2016). Epsin. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101568-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101568-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics

Search

Navigation