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RHEB

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules

  • 127 Accesses

Synonyms

Ras homologue enriched in brain

Historical Background

Rheb (Ras homologue enriched in brain) was originally identified as a small guanosine triphosphate (GTP)-binding protein upregulated in the brain in response to electroconvulsive shock (Yamagata et al. 1994). Despite its name, Rheb protein is ubiquitously expressed in a variety of tissues. Rheb is evolutionarily conserved between yeast and humans, and it belongs to the Ras subfamily. In mammals, two different Rheb genes have been identified: Rheb and RhebL (also called Rheb1 and Rheb2, respectively). Since the Rheb GTPase was found to be regulated by the Tsc1 and Tsc2 proteins, which are responsible for the tuberous sclerosis complex (TSC) (Pan et al. 2004), Rheb functions have been extensively investigated. Moreover, Rheb has been demonstrated to activate the mammalian target of rapamycin (mTOR) signaling pathway and to regulate protein translation, cell proliferation, cell size, and metabolism.

Protein and Gene Structure

T...

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References

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Authors and Affiliations

  1. Synaptic Plasticity Project, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, 156-8506, Japan

    Tadayuki Shimada, Hiroko Sugiura & Kanato Yamagata

Authors
  1. Tadayuki Shimada
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  2. Hiroko Sugiura
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  3. Kanato Yamagata
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Corresponding author

Correspondence to Tadayuki Shimada .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Shimada, T., Sugiura, H., Yamagata, K. (2016). RHEB. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101555-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101555-1

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  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

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