Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

Peroxisome Proliferator-Activated Receptor Alpha (PPAR-Alpha)

  • Herman E. Popeijus
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101552-1

Synonyms

Historical Background

The first peroxisome proliferator-activated receptor or PPAR was discovered as hormone receptor that was activated by rodent hepatocarcinogens that induced peroxisome proliferation (Issemann and Green 1990). PPARs are now known as a group of transcription factors that are able to induce transcription of genes that contain PPAR responsive elements (PPREs). The PPAR family of transcription factors consist of PPARα, β of δ (or nuclear receptor subfamily 1, group C, member 2 (NR1C2)), and γ (or nuclear receptor subfamily 1, group C, member 3 NR1C3). Here the focus is on PPARα that, in humans, is mainly expressed in tissue with high fatty acid oxidation like liver, muscle, heart, and kidney though also many other tissues do show expression of this family member. PPARα is thought to be a master regulator of lipid metabolism. It does so by...

Keywords

Nonalcoholic Fatty Liver Disease Nuclear Receptor Subfamily Induce Peroxisome Proliferation PPAR Responsive Element Liver Tumor Development 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  1. 1.Department of Human BiologyMaastricht UniversityMaastrichtThe Netherlands