Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

CCAAT/Enhancer-Binding Protein Beta

  • Herman E. Popeijus
  • Sophie E. van der Krieken
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101550-1

Synonyms

Historical Background

The nuclear factor for IL-6 expression (NF-IL6) was discovered as a member of the CCAAT-enhancer binding proteins (C/EBP) in 1990, from which it derived its current name: C/EBP-β (Akira et al. 1990). C/EBP-β was first found to bind to an interleukin 1 (IL1) responsive element necessary for IL-6 expression (Akira et al. 1990). In general, C/EBP-β is thought to be an important transcription factor involved in immune responses, hematopoiesis, endoplasmic reticulum stress (ER-stress), adipogenesis, central nervous system (CNS) diseases, gluconeogenesis, liver regeneration, and embryogenesis. The C/EBP protein family consists of six members: C/EBP-α, -β, -δ, -ε, -γ, and -ζ (Gene names CEBPA, CEBPB, CEBPG, CEBPD, CEBPE, and CEBPZ, respectively). Each member belongs to the basic-leucine...

Keywords

Endoplasmic Reticulum Stress Duchenne Muscular Dystrophy Clonal Expansion Duchenne Muscular Dystrophy Cancer Cachexia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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References

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Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Herman E. Popeijus
    • 1
  • Sophie E. van der Krieken
    • 1
  1. 1.Department of Human BiologyMaastricht UniversityMaastrichtThe Netherlands