Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi

CCAAT/Enhancer-Binding Protein Beta

  • Herman E. Popeijus
  • Sophie E. van der Krieken
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101550-1


Historical Background

The nuclear factor for IL-6 expression (NF-IL6) was discovered as a member of the CCAAT-enhancer binding proteins (C/EBP) in 1990, from which it derived its current name: C/EBP-β (Akira et al. 1990). C/EBP-β was first found to bind to an interleukin 1 (IL1) responsive element necessary for IL-6 expression (Akira et al. 1990). In general, C/EBP-β is thought to be an important transcription factor involved in immune responses, hematopoiesis, endoplasmic reticulum stress (ER-stress), adipogenesis, central nervous system (CNS) diseases, gluconeogenesis, liver regeneration, and embryogenesis. The C/EBP protein family consists of six members: C/EBP-α, -β, -δ, -ε, -γ, and -ζ (Gene names CEBPA, CEBPB, CEBPG, CEBPD, CEBPE, and CEBPZ, respectively). Each member belongs to the basic-leucine...


Endoplasmic Reticulum Stress Duchenne Muscular Dystrophy Clonal Expansion Duchenne Muscular Dystrophy Cancer Cachexia 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Herman E. Popeijus
    • 1
  • Sophie E. van der Krieken
    • 1
  1. 1.Department of Human BiologyMaastricht UniversityMaastrichtThe Netherlands