CCAAT/Enhancer-Binding Protein Beta
Living reference work entry
The nuclear factor for IL-6 expression (NF-IL6) was discovered as a member of the CCAAT-enhancer binding proteins (C/EBP) in 1990, from which it derived its current name: C/EBP-β (Akira et al. 1990). C/EBP-β was first found to bind to an interleukin 1 (IL1) responsive element necessary for IL-6 expression (Akira et al. 1990). In general, C/EBP-β is thought to be an important transcription factor involved in immune responses, hematopoiesis, endoplasmic reticulum stress (ER-stress), adipogenesis, central nervous system (CNS) diseases, gluconeogenesis, liver regeneration, and embryogenesis. The C/EBP protein family consists of six members: C/EBP-α, -β, -δ, -ε, -γ, and -ζ (Gene names CEBPA, CEBPB, CEBPG, CEBPD, CEBPE, and CEBPZ, respectively). Each member belongs to the basic-leucine...
KeywordsEndoplasmic Reticulum Stress Duchenne Muscular Dystrophy Clonal Expansion Duchenne Muscular Dystrophy Cancer Cachexia
- Bai Y, Wei Y, Wu L, Wei J, Wang X, Bai Y. C/EBP beta mediates endoplasmic reticulum stress regulated inflammatory response and extracellular matrix degradation in LPS-stimulated human periodontal ligament cells. Int J Mol Sci. 2016;17:385. doi:10.3390/ijms17030385.CrossRefPubMedPubMedCentralGoogle Scholar
- Bamberger AM, Makrigiannakis A, Schroder M, Bamberger CM, Relakis C, Gellersen B, et al. Expression pattern of the CCAAT/enhancer-binding proteins C/EBP-alpha, C/EBP-beta and C/EBP-delta in the human placenta. Virchows Arch. 2004;444:149–52. doi:10.1007/s00428-003-0935-7.CrossRefPubMedGoogle Scholar
- Lala-Tabbert N, Fu D, Wiper-Bergeron N. Induction of CCAAT/enhancer-binding protein beta expression with the phosphodiesterase inhibitor isobutylmethylxanthine improves myoblast engraftment into dystrophic muscle. Stem Cells Transl Med. 2016;5:500–10. doi:10.5966/sctm.2015-0169.CrossRefPubMedPubMedCentralGoogle Scholar
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