Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


  • Suchismita Roy
  • Prabhjeet Singh
  • Sneh Lata Singla-Pareek
  • Ashwani Pareek
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101549-1


Historical Background

The first cyclophilin (Cyp/PPIases: EC was isolated more than three decades ago as an intracellular receptor of the immunosuppressive drug cyclosporine A (CsA) from the bovine thymocyctes (Handschumacher et al. 1984). It was not until 1989, its PPIase activity was elucidated. Cyclophilins comprise a ubiquitous set of proteins which is present across diverse genera of organisms. The single domain cyclophilin has a single cyclophilin-like domain (CLD), whereas multidomain cyclophilins also possess additional domains such as tetratricopeptide repeat (TPR), RNA recognition motif (RRM), tryptophan aspartate domain (WD40), coiled-coil domain (CCD), and internal repeats domain (RPT). Cyclophilins are involved in a myriad of physiological cellular processes, such as protein trafficking and maturation, receptor complex stabilization, apoptosis, receptor...


PPIase Activity PPIase Domain Extracellular Receptor Kinase Cyclophilin Inhibitor Abdominal Aortic Aneurysm Formation 
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© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Suchismita Roy
    • 1
  • Prabhjeet Singh
    • 2
  • Sneh Lata Singla-Pareek
    • 3
  • Ashwani Pareek
    • 1
  1. 1.School of Life SciencesJawaharlal Nehru UniversityNew DelhiIndia
  2. 2.Department of BiotechnologyGuru Nanak Dev UniversityAmritsarIndia
  3. 3.Plant Stress BiologyICGEBNew DelhiIndia