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Encyclopedia of Signaling Molecules pp 1–7Cite as

Natriuretic Peptide Receptor Type A (NPRA)

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Synonyms

ANPa; ANPRA; GCA; GC-A; GUC2A; GUCY2; NPR1 (natriuretic peptide receptor 1); NPRA; NPR-A

Historical Background

Atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), C-type natriuretic peptide (CNP), and urodilatin (URO) represent a family of cardiac, vascular, and renal-derived hormones that play an essential role on the regulation of blood pressure, intravascular volume, and electrolyte homeostasis in all mammals. Most of the biological actions of ANP, BNP, and URO are mediated by activation of the natriuretic peptide receptor type A (NPRA), also designated as guanylyl cyclase-A/ natriuretic peptide receptor type A (GC-A/NPRA). Binding of these natriuretic peptides to NPRA leads to activation of the particulate guanylate cyclase (pGC) catalytic domain which generates cGMP-dependent second messenger signaling cascade. An increased level of intracellular cGMP activates three different targets: cGMP-dependent protein kinases (PKGs), cGMP-dependent ion-gated...

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Authors and Affiliations

  1. Instituto de Investigaciones Cardiológicas “Prof. Dr. Alberto C. Taquini”, ININCA, UBA-CONICET, Marcelo T de Alvear 2270, 4th floor, 1122, Buenos Aires, Argentina

    Natalia L. Rukavina Mikusic, María I. Rosón, Nicolás M. Kouyoumdzian, Belisario E. Fernández & Marcelo R. Choi

  2. Facultad de Farmacia y Bioquímica, Cátedra de Anatomía e Histología, Universidad de Buenos Aires, Junín 956, 1st floor, 1113, Buenos Aires, Argentina

    Silvana M. Cantú & Marcelo R. Choi

Authors
  1. Natalia L. Rukavina Mikusic
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  2. María I. Rosón
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  3. Nicolás M. Kouyoumdzian
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  4. Silvana M. Cantú
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  5. Belisario E. Fernández
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  6. Marcelo R. Choi
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Corresponding author

Correspondence to Natalia L. Rukavina Mikusic .

Editor information

Editors and Affiliations

  1. Dept. Biological Science, Department of Molecular Science and Tech College of Natural Science, Suwon, Korea (Republic of)

    Sangdun Choi

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Mikusic, N.L.R., Rosón, M.I., Kouyoumdzian, N.M., Cantú, S.M., Fernández, B.E., Choi, M.R. (2016). Natriuretic Peptide Receptor Type A (NPRA). In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101545-1

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  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101545-1

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4614-6438-9

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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