Encyclopedia of Signaling Molecules

Living Edition
| Editors: Sangdun Choi


  • Rosario Donato
  • Guglielmo Sorci
  • Ileana Giambanco
Living reference work entry
DOI: https://doi.org/10.1007/978-1-4614-6438-9_101531-1


Historical Background

S100A6 belongs to the S100 family of Ca2+-binding proteins of the EF-hand type (reviewed in Donato et al. 2013). As a member of the A group of S100 proteins, human S100A6 gene maps to chromosome 1q21. S100A6 is expressed as an 89-amino-acid protein in mouse and rat and a 90-amino-acid protein in human and rabbit. Two chicken isoforms, A (92 amino acids) and B (91 amino acids), probably result from alternative mRNA splicing. S100A6 from all these sources differs in only a few amino acids and in the length of the carboxy terminus. The S100A6 gene was initially identified in growth-arrested rodent fibroblasts stimulated with serum and suggested to have a role in cell-cycle progression as inferred by its upregulation in several tumors (reviewed in Leśniak et al. 2009). S100A6 was found to interact with...


Amyotrophic Lateral Sclerosis S100A6 Protein S100A6 Expression S100A6 Gene Colorectal Carcinoma Cell Line 
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  1. Botelho HM, Leal SS, Cardoso I, Yanamandra K, Morozova-Roche LA, Fritz G, Gomes CM. S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation. J Biol Chem. 2012;287:42233–42.CrossRefPubMedPubMedCentralGoogle Scholar
  2. Cai XY, Lu L, Wang YN, Jin C, Zhang RY, Zhang Q, Chen QJ, Shen WF. Association of increased S100B, S100A6 and S100P in serum levels with acute coronary syndrome and also with the severity of myocardial infarction in cardiac tissue of rat models with ischemia-reperfusion injury. Atherosclerosis. 2011;217:536–42.CrossRefPubMedGoogle Scholar
  3. Chen H, Xu C, Jin Q, Liu Z. S100 protein family in human cancer. Am J Cancer Res. 2014;4:89–115.PubMedPubMedCentralGoogle Scholar
  4. Chen X, Liu X, Lang H, Zhang S, Luo Y, Zhang J. S100 calcium-binding protein A6 promotes epithelial-mesenchymal transition through β-catenin in pancreatic cancer cell line. PLoS One. 2015;10:e0121319.CrossRefPubMedPubMedCentralGoogle Scholar
  5. Donato R, Cannon BR, Sorci G, Riuzzi F, Hsu K, Weber DJ, Geczy CL. Functions of S100 proteins. Curr Mol Med. 2013;13:24–57.CrossRefPubMedPubMedCentralGoogle Scholar
  6. Graczyk A, Leśniak W. S100A6 expression in keratinocytes and its impact on epidermal differentiation. Int J Biochem Cell Biol. 2014;57:135–41.CrossRefPubMedGoogle Scholar
  7. Graczyk A, Słomnicki LP, Leśniak W. S100A6 competes with the TAZ2 domain of p300 for binding to p53 and attenuates p53 acetylation. J Mol Biol. 2013;425:3488–94.CrossRefPubMedGoogle Scholar
  8. Jurewicz E, Góral A, Filipek A. S100A6 is secreted from Wharton’s jelly mesenchymal stem cells and interacts with integrin β1. Int J Biochem Cell Biol. 2014;55:298–303.CrossRefPubMedGoogle Scholar
  9. Leśniak W, Słomnicki ŁP, Filipek A. S100A6 – new facts and features. Biochem Biophys Res Commun. 2009;390:1087–92.CrossRefPubMedGoogle Scholar
  10. Li Y, Wagner ER, Yan Z, Wang Z, Luther G, Jiang W, Ye J, Wei Q, Wang J, Zhao L, Lu S, Wang X, Mohammed MK, Tang S, Liu H, Fan J, Zhang F, Zou Y, Song D, Liao J, Haydon RC, Luu HH, He TC. The calcium-binding protein S100A6 accelerates human osteosarcoma growth by promoting cell proliferation and inhibiting osteogenic differentiation. Cell Physiol Biochem. 2015;37:2375–92.CrossRefPubMedGoogle Scholar
  11. Lyu XJ, Li HZ, Ma X, Li XT, Gao Y, Ni D, Shen DL, Gu LY, Wang BJ, Zhang Y, Zhang X. Elevated S100A6 (Calcyclin) enhances tumorigenesis and suppresses CXCL14-induced apoptosis in clear cell renal cell carcinoma. Oncotarget. 2015;6:6656–69.CrossRefPubMedPubMedCentralGoogle Scholar
  12. Mohan SK, Gupta AA, Yu C. Interaction of the S100A6 mutant (C3S) with the V domain of the receptor for advanced glycation end products (RAGE). Biochem Biophys Res Commun. 2013;434:328–33.CrossRefPubMedGoogle Scholar
  13. Nishi M, Matsumoto K, Kobayashi M, Yanagita K, Matsumoto T, Nagashio R, Ishii D, Fujita T, Sato Y, Iwamura M. Serum expression of S100A6 is a potential detection marker in patients with urothelial carcinoma in the urinary bladder. Biomed Res. 2014;35:351–6.CrossRefPubMedGoogle Scholar
  14. Otterbein LR, Kordowska J, Witte-Hoffmann C, Wang CL, Dominguez R. Crystal structures of S100A6 in the Ca(2+)-free and Ca(2+)-bound states: the calcium sensor mechanism of S100 proteins revealed at atomic resolution. Structure. 2002;10:557–67.CrossRefPubMedGoogle Scholar
  15. Tamai H, Miyake K, Yamaguchi H, Shimada T, Dan K, Inokuchi K. Inhibition of S100A6 induces GVL effects in MLL/AF4-positive ALL in human PBMC-SCID mice. Bone Marrow Transplant. 2014;49:699–703.CrossRefPubMedGoogle Scholar
  16. Tsoporis JN, Marks A, Haddad A, O’Hanlon D, Jolly S, Parker TG. S100A6 is a negative regulator of the induction of cardiac genes by trophic stimuli in cultured rat myocytes. Exp Cell Res. 2005;303(2):471–8.CrossRefPubMedGoogle Scholar
  17. Wang T, Liang Y, Thakur A, Zhang S, Yang T, Chen T, Gao L, Chen M, Ren H. Diagnostic significance of S100A2 and S100A6 levels in sera of patients with non-small cell lung cancer. Tumour Biol. 2016;37:2299–304.CrossRefPubMedGoogle Scholar
  18. Wasik U, Kadziolka B, Kilanczyk E, Filipek A. Influence of S100A6 on CacyBP/SIP phosphorylation and Elk-1 transcriptional activity in neuroblastoma NB2a cells. Cell Biochem. 2016;117:126–31.CrossRefGoogle Scholar
  19. Yamada J, Jinno S. S100A6 (calcyclin) is a novel marker of neural stem cells and astrocyte precursors in the subgranular zone of the adult mouse hippocampus. Hippocampus. 2014;24:89–101.CrossRefPubMedGoogle Scholar
  20. Zhang J, Zhang K, Jiang X, Zhang J. S100A6 as a potential serum prognostic biomarker and therapeutic target in gastric cancer. Dig Dis Sci. 2014;59:2136–44.CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media LLC 2016

Authors and Affiliations

  • Rosario Donato
    • 1
    • 2
    • 3
  • Guglielmo Sorci
    • 1
    • 3
  • Ileana Giambanco
    • 1
  1. 1.Department of Experimental Medicine, Perugia Medical SchoolUniversity of PerugiaPerugiaItaly
  2. 2.Centro Universitario per la Ricerca sulla Genomica FunzionaleUniversity of PerugiaPerugiaItaly
  3. 3.Istituto Interuniversitario di Miologia (Interuniversity Institute for Myology), Perugia Medical SchoolUniversity of PerugiaPerugiaItaly