Skip to main content

ENaC

  • Living reference work entry
  • First Online:
Encyclopedia of Signaling Molecules
  • 79 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Institutional subscriptions

References

  • Barbry P, Champe M, Chassande O, Munemitsu S, Champigny G, Lingueglia E, et al. Human kidney amiloride-binding protein: cDNA structure and functional expression. Proc Natl Acad Sci U S A. 1990;87:7347–51.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Benos DJ, Saccomani G, Sariban-Sohraby S. The epithelial sodium channel. Subunit number and location of the amiloride binding site. J Biol Chem. 1987;262:10613–8.

    CAS  PubMed  Google Scholar 

  • Canessa CM, Horisberger JD, Rossier BC. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature. 1993;361:467–70. doi:10.1038/361467a0.

    Article  CAS  PubMed  Google Scholar 

  • Canessa CM, Schild L, Buell G, Thorens B, Gautschi I, Horisberger JD, et al. Amiloride-sensitive epithelial Na+ channel is made of three homologous subunits. Nature. 1994;367:463–7. doi:10.1038/367463a0.

    Article  CAS  PubMed  Google Scholar 

  • Frazier HS. The electrical potential profile of the isolated toad bladder. J Gen Physiol. 1962;45:515–28.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Frazier HS, Dempsey EF, Leaf A. Movement of sodium across the mucosal surface of the isolated toad bladder and its modification by vasopressin. J Gen Physiol. 1962;45:529–43.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hanukoglu I, Hanukoglu A. Epithelial sodium channel (ENaC) family: phylogeny, structure-function, tissue distribution, and associated inherited diseases. Gene. 2016;579:95–132. doi:10.1016/j.gene.2015.12.061.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ji HL, Zhao RZ, Chen ZX, Shetty S, Idell S, Matalon S. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Phys Lung Cell Mol Phys. 2012;303:L1013–26. doi:10.1152/ajplung.00206.2012.

    CAS  Google Scholar 

  • Leaf A, Anderson J, Page LB. Active sodium transport by the isolated toad bladder. J Gen Physiol. 1958;41:657–68.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lindemann B, Van Driessche W. Sodium-specific membrane channels of frog skin are pores: current fluctuations reveal high turnover. Science. 1977;195:292–4.

    Article  CAS  PubMed  Google Scholar 

  • Lingueglia E, Voilley N, Waldmann R, Lazdunski M, Barbry P. Expression cloning of an epithelial amiloride-sensitive Na+ channel. A new channel type with homologies to Caenorhabditis elegans degenerins. FEBS Lett. 1993;318:95–9.

    Article  CAS  PubMed  Google Scholar 

  • Pao AC. There and back again: insulin, ENaC, and the cortical collecting duct. Phys Rep. 2016;4(10):e12809. doi:10.14814/phy2.12809.

    Google Scholar 

  • Park CS, Fanestil DD. Covalent modification and inhibition of an epithelial sodium channel by tyrosine-reactive reagents. Am J Phys. 1980;239:F299–306.

    CAS  Google Scholar 

  • Rossier BC, Pradervand S, Schild L, Hummler E. Epithelial sodium channel and the control of sodium balance: interaction between genetic and environmental factors. Annu Rev Physiol. 2002;64:877–97. doi:10.1146/annurev.physiol.64.082101.143243.

    Article  CAS  PubMed  Google Scholar 

  • Rossier BC, Baker ME, Studer RA. Epithelial sodium transport and its control by aldosterone: the story of our internal environment revisited. Physiol Rev. 2015;95:297–340. doi:10.1152/physrev.00011.2014.

    Article  PubMed  Google Scholar 

  • Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012;47:349–59. doi:10.3109/10409238.2012.678285.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M. Molecular cloning and functional expression of a novel amiloride-sensitive Na+ channel. J Biol Chem. 1995;270:27411–4.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Hong-Long Ji .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer Science+Business Media LLC

About this entry

Cite this entry

Liu, Y., Ji, HL. (2016). ENaC. In: Choi, S. (eds) Encyclopedia of Signaling Molecules. Springer, New York, NY. https://doi.org/10.1007/978-1-4614-6438-9_101527-1

Download citation

  • DOI: https://doi.org/10.1007/978-1-4614-6438-9_101527-1

  • Received:

  • Accepted:

  • Published:

  • Publisher Name: Springer, New York, NY

  • Online ISBN: 978-1-4614-6438-9

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

Publish with us

Policies and ethics